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Design Based Research (DBR) is a new and still-emerging approach to research about design, learning, and allied areas. This article reports one designer’s experiences within a DBR project. Whereas most reports of DBR focus on the outcomes of the design itself, the current paper offers a hermeneutical perspective by focusing on the personal narrative of the designer. Using Edelson’s (2002) categ...
The objective of this study was to examine the suitability of multiplex ligation-dependent probe amplification (MLPA) in chorionic villus samples as a replacement for traditional karyotyping for the detection of (an)euploidies of chromosomes 21, 18, 13, X, and Y. Chorionic villus samples were diagnosed by traditional karyotyping using short-term cultures (STC) and long-term cultures (LTC), and ...
*Correspondence: Zhen Cheng, Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, 1201 Welch Road, Lucas Expansion, P095 Stanford University, Stanford, CA 94305, USA e-mail: [email protected] Cerenkov radiation (CR) has been used in various biological research fields, which has aroused lots of attention in rece...
BACKGROUND The major aneuploidies that are diagnosed prenatally involve the autosomal chromosomes 13, 18, and 21, as well as sex chromosomes, X and Y. Because multiplex ligation-dependent probe amplification (MLPA) is rapid and non-invasive, it has replaced traditional culture methods for the screening and diagnosis of common aneuploidies in some countries. OBJECTIVE To evaluate the sensitivi...
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