Six ruminally and duodenally cannulated yearling steers (523 kg) were used in a replicated 3 x 3 Latin square design experiment to study the effects of corn processing on nutrient digestion, bacterial CP production, and ruminal fermentation. Dietary treatments consisted of 90% concentrate diets that were based on dry-rolled (DRC), high-moisture (HMC), or steam-flaked (SFC) corn. Each diet conta...

fab (french – american- british) group determined a diagnostic classification for leukemia's. but in spite of some reports on different clinical findings and prognosis of hmc and lgl there is no place for hand- mirror cell leukemia and lgl leukemia in this classification. on the other hand, there are different ideas about causes of hand mirror cell and about different changes of large granlar l...

I discuss the behaviour of algorithms for dynamical fermions as the sea-quark mass decreases. I focus on the Hybrid-Monte-Carlo (HMC) algorithm applied to two degenerate flavours of Wilson fermions. First, I briefly review the performance obtained in large scale HMC simulations. Then I discuss a modified pseudo-fermion action for the HMC simulation that has been introduced three years ago. I su...

The restoration of a hidden process X from an observed process Y is often performed in the framework of hidden Markov chains (HMC). HMC have been recently generalized to triplet Markov chains (TMC). In the TMC model one introduces a third random chain U and assumes that the triplet T = (X,U, Y ) is a Markov chain (MC). TMC generalize HMC but still enable the development of efficient Bayesian al...

Melanomas in the vertical growth phase (VGP) not infrequently demonstrate cellular heterogeneity. One commonly encountered subpopulation displays small cell/nevoid morphology. Although its significance remains unknown, such subpopulations may pose diagnostic issues when faced with differentiating such changes from associated nevus or mistaking such regions for nevic maturation (pseudomaturation...

The echocardiographic findings of eight patients with hypertrophic cardiomyopathy without outflow obstruction (HMC) and of 15 normal (Norm) individuals are presented. The characteristic features in HMC were: (1) interventricular septal width much greater than normal (HMC= 2.5 + 0.3 cm, Norm = 1.0 + 0.2 cm, P <0.005); (2) normal or only slightly increased posterior left ventricular wall thicknes...

Abnormal lipid accumulation in glomeruli could be implicated in the pathogenesis of glomerulosclerosis. Low-density lipoprotein (LDL) stimulates collagen mRNA expression in cultured human mesangial cells (HMC). To explore the possible molecular mechanisms by which LDL promotes collagen gene expression, we examined the effects of LDL on protein kinase C (PKC) activity and transforming growth fac...

Post-translational modifications in lens proteins are key causal factors in cataract. As the most abundant post-translational modification in the lens, racemization may be closely related to the pathogenesis of cataract. Racemization of αA-crystallin, a crucial structural and heat shock protein in the human lens, could significantly influence its structure and function. In previous studies, ele...

Recent evidence has shown that the level of 5-hydroxymethylcytosine (5 hmC) in chromosomal DNA is aberrantly decreased in a variety of cancers, but whether this decrease is a cause or a consequence of tumorigenesis is unclear. Here we show that, in gastric cancers, the 5 hmC decrease correlates with a decrease in ten-eleven translocation 1 (TET1) expression, which is strongly associated with me...

BACKGROUND Evidence has supported a role of DNA methylation in the pathophysiology of mood disorders. The purpose of the current study is to examine 5-methylcytosine (5-mc) and 5-hydroxymethylcytosine (5-hmc) levels in patients with major depressive disorder (MDD) at different disease states. METHODS Forty-nine patients with MDD and 25 healthy control subjects were included. The severity in t...