This paper describes a framework for developing applications that conform to Systems Application Architecture (SAA). The paper shows a high-level approach to creating a design; it gives examples of early modeling work with the user interface; and it appraises SAA through the eyes of several system designers. The usability of user interfaces has been evaluated through the modeling of office task...

Dietary copper deficiency increases the accumulation of circulating neutrophils in the rat lung microcirculation. This process includes neutrophil adhesion to, migration along, and emigration though the vascular endothelium. The current study was designed to examine the role of copper in each of these steps. Neutrophils were isolated from rats fed either a copper-adequate (CuA, 6.1 microg Cu/g ...

INTRODUCTION Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare disease most frequently occurring in patients with advanced chronic kidney disease (CKD). The clinical picture is typically characterized by very painful skin lesions and ulcerations following calcification and occlusion of small cutaneous arterioles. CUA is life-threatening due to infections and concomita...