Circumscribed palmoplantar hypokeratosis (CPH) is a rare acquired dermatosis first described in 2002. It affects mostly the thenar or hypothenar eminences of palm middle-aged elderly women and manifests clinically with sharply limited, annular erythematous plaques depressed surface, rimmed by slightly raised, keratotic border. Microscopically, circumscribed shows sharp decrease horny layer thic...

BACKGROUND Palmoplantar psoriasis is a difficult to treat variant of plaque psoriasis. OBJECTIVE To study the safety and efficacy of infliximab in non-pustular palmoplantar psoriasis. METHODS Patients with non-pustular palmoplantar psoriasis affecting at least 10% of their palms and soles and with a modified palmoplantar psoriasis area and severity index (m-PPPASI) of at least eight were re...

Although palmoplantar psoriasis can be severely disabling, there are very few large clinico-epidemiological studies on this condition. Our purpose was to study the morphology and pattern of lesions in Indian patients with palmoplantar psoriasis and to elucidate the role of occupation in the incidence/localization of these lesions. All patients attending our Psoriasis Clinic from 1993 to 2000 we...

Background. Warts are cutaneous and, sometimes, mucosal lesions caused by one of the several human papilloma viruses. Aim. Assessment of the clinicoepidemiological aspects of warts. Materials and Methods. One hundred consecutive patients of warts presenting to the department of our institution were assigned two broad locational groups: genital and nongenital warts, the latter subdivided into co...

INTRODUCTION Palmoplantar psoriasis is an uncommon clinical form of psoriasis. Although localized to the palms and soles, it has a considerable impact on the patient's function and quality of life. OBJECTIVES To study the effectiveness and safety of psoralen-UV-A (PUVA) therapy in palmoplantar psoriasis and investigate predictors of clinical response. MATERIAL AND METHODS We performed a ret...

introduction: papillon-lefèvre syndrome(pls) characterized by palmoplantar hyperkeratosis is a rare autosomal recessive genetic disorder with rapidly progressive periodontitis and premature loss of both deciduous and permanent teeth. in this study, we report the clinical and radiographic features of papillon-lefèvre syndrome in an 11- year-old girl and we also discuss the history and various th...

Mal de Meleda is a rare transgressive palmoplantar keratoderma with an estimated prevalence of 1 in 100,000 individuals. It was first described in 1826 by Stulli on the island of Mljet. Its autosomal recessive inheritance was described in 1938, and the defective gene was localized to chromosome 8 qter in 1998. Clinical features are the result of abnormal palmoplantar keratinization and include ...

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accord...

IL: interleukin INTRODUCTION Psoriasis is a common chronic disease andmay be the most prevalent autoimmune disease. The estimated prevalence is 2% to 4% of the global population. Fortunately, providers have a plethora of medications to choose from, but even so, some cases can be very difficult to treat. Herein, we present a challenging case of palmoplantar pustulosis primarily affecting the sol...