Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a transmembrane glycoprotein that is involved in tumor progression and metastasis. In the present study, the expression and functional role of ALCAM in pancreatic cancer cells and pancreatic stellate cells (PSCs) was investigated. Tissue specimens were obtained from patients with pancreatic ductal adenocarcinoma (n=56) or chronic pancr...

Abstract Background We previously demonstrated that nuclear BCL10 translocation participates in the instigation of NF-?B breast cancer and lymphoma cell lines. In this study, we assessed whether is clinically significant advanced metastatic pancreatic ductal adenocarcinoma (PDAC). Method materials analyzed expression BCL10-, cycle-, NF-?B- related signaling molecules, DNA-binding activity three...

As Plantas Alimentícias Não Convencionais (PANC) consistem em um conjunto de espécies grande valor nutricional, socioeconômico e cultural têm sido cada vez mais inseridas nos debates nacionais internacionais sobre alimentação adequada produção sustentável. Nesse artigo, as PANC são apresentadas como uma estratégia para diversificação dos sistemas produção, promoção autonomia no campo nas cidade...

Mycobacterium tuberculosis, the main cause of tuberculosis (TB), has still remained a global health crisis especially in developing countries. Tuberculosis treatment is a laborious and lengthy process with high risk of non compliance, cytotoxicity adverse events and drug resistance in patient. Recently, there has been an alarming rise of drug resistant in TB. In this regard, it is an unmet need...

HYPOTHESIS Pancreatic cystic neoplasms and ductal adenocarcinoma manifest diverse clinical features and prognoses, which might be related to cellular distribution of ezrin modulated through various trophic molecules. DESIGN Laboratory investigation and retrospective analysis. SETTING Medical school-affiliated university hospital. PATIENTS AND METHODS Patients with solid pseudopapillary tu...

Neste trabalho, foi avaliado o potencial das plantas alimentícias não convencionais (PANC) no fornecimento de recursos para as abelhas e seu uso na intensificação ecológica. O Assentamento São José da Boa Morte (Cachoeiras Macacu, Estado do Rio Janeiro, Brasil) tomado como estudo caso, onde realizado os levantamentos PANC espontâneas calendário cultivo comunidade. Foram encontradas 28 espécies ...

BACKGROUND TGF-β-activated kinase-1 (TAK1), a mitogen-activated protein kinase kinase kinase, functions in the activation of nuclear factor κB (NF-κB) and activator protein-1, which can suppress proapoptotic signaling pathways and thus promote resistance to chemotherapeutic drugs. However, it is not known if inhibition of TAK1 is effective in reducing chemoresistance to therapeutic drugs agains...

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various types of cancer cells without damaging normal cells. However, in terms of pancreatic cancer, not all cancer cells are sensitive to TRAIL. In this study, we examined a panel of human pancreatic cancer cell lines for TRAIL sensitivity and investigated the effects of Bcl-2 family inhibitors on their ...

The goal of the study was to assess the efficacy of combined extracellular matrix metalloprotease inducer (EMMPRIN)and death receptor 5 (DR5)-targeted therapy for pancreatic adenocarcinoma in orthotopic mouse models with multimodal imaging. Cytotoxicity of anti-EMMPRIN antibody and anti-DR5 antibody (TRA-8) in MIA PaCa-2 and PANC-1 cell lines was measured by ATPlite assay in vitro. The distribu...