Human papillomavirus (HPV) infection is the leading cause of cervical cancer world-wide. Here, we show that native HPV particles produced in a differentiated epithelium have developed different strategies to infect the host. Using biochemical inhibition assays and glycosaminoglycan (GAG)-negative cells, we show that of the four most common cancer-causing HPV types, HPV18, HPV31, and HPV45 are l...

Although the association and clinical significance of human papillomavirus (HPV) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of HPV in laryngeal cancer has been inadequately evaluated. Herein we review the currently known associations of HPV infections in diseases of the larynx and their potentia...

Human papillomaviruses (HPVs) are prevalent pathogens of mucosal and cutaneous epithelia. Productive infections of squamous epithelia lead to benign hyperproliferative warts, condylomata, or papillomas. Persistent infections of the anogenital mucosa by high-risk HPV genotypes 16 and 18 and closely related types can infrequently progress to high-grade intraepithelial neoplasias, carcinomas-in-si...

Human papillomaviruses (HPVs) comprise more than 100 genotypes. The mucosal types can be divided into high-risk and low-risk (LR) types depending on the associated disease risk. HPV infection is mainly diagnosed by molecular methods, since reliable serological tools are not available and culture of the virus is not possible. Accurate molecular diagnostic techniques that can be used to inform pa...

Most infections by human papillomaviruses (HPVs) are `acute', that is non-persistent. Yet, for HPVs, as for many other oncoviruses, there is a striking gap between our detailed understanding of chronic infections and our limited data on the early stages of infection. Here we argue that studying HPV acute infections is necessary and timely. Focusing on early interactions will help explain why ce...

Human Papillomavirus (HPV) infection is very common. It is estimated as the most common sexually transmitted disease, (high risk human papillomavirus are the necessary causes of cervical cancer) [1]. More than 100 types of HPV have been identified which can be classified as high-risk or low-risk depending on their known oncogenic activity. The vast majority of cervical cancers infections with H...

The incidence of penile cancer varies worldwide, with the highest burden in some developing countries, particularly in Africa and South America. This indicates that environmental factors play an important role. Chronic papillomavirus infections have been identified with increasing frequency. Non-viral infections due to poor hygienic conditions are also established risk factors and this is under...

The oral cavity is particularly susceptible to viral infections because of its conformation, soft tissue and salivary glands. Several viruses, including herpes simplex virus (HSV) human papillomavirus (HPV), are associated with disease-causing primary lesions. Prions smaller than viruses can only be seen through an electron microscope when they have aggregated formed a cluster. also unique in t...

Oncogenic human papillomavirus (HPV) infection is the main etiologic factor for cervical neoplasia, although infection alone is insufficient to produce disease. Cofactors such as nutritional factors may be necessary for viral progression to neoplasia. Results from previous studies have suggested that higher dietary consumption and circulating levels of certain micronutrients may be protective a...

OBJECTIVE To evaluate the expected change in the prevalence of male circumcision (MC)-reduced infections and resulting health care costs associated with continued decreases in MC rates. During the past 20 years, MC rates have declined from 79% to 55%, alongside reduced insurance coverage. DESIGN We used Markov-based Monte Carlo simulations to track men and women throughout their lifetimes as ...