BACKGROUND The role of biomarkers for prognostication and diagnosis of pulmonary embolism (PE) is increasing. It has been reported that pregnancy-associated plasma protein-A (PAPP-A) can be used as a proatherosclerotic marker. The present study was aimed to evaluate whether PAPP-A levels are helpful in the differential diagnosis of patients presenting with suspected PE. METHODS 53 consecutive...

The POLDER radiometer was on board the ADEOS satellite from August 1996 to June 1997. This instrument measures radiances in eight narrow spectral bands of the visible and near infrared spectrum. Two of them are centered on the 02 A-band in order to infer cloud pressure. By assuming the atmosphere behaves as a pure absorbing medium overlying a perfect reflector, an "apparent" pressure Papp is de...

Proteolytic cleavage of the six known insulin-like growth factor binding proteins (IGFBPs) is a powerful means of rapid structure and function modification of these important growth-regulatory proteins. Intact IGFBP-4 is a potent inhibitor of IGF action in vitro, and cleavage of IGFBP-4 has been shown to abolish its ability to inhibit IGF stimulatory effects in a variety of systems, suggesting ...

OBJECTIVE To determine whether the maternal serum levels of adiponectin in the first trimester of pregnancy are altered in cases that develop preeclampsia (PE) and whether the levels are related to pregnancy-associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (PI). METHODS Serum adiponectin, PAPP-A and uterine artery PI were measured at 11-13 weeks in 90 cases that devel...

OBJECTIVE To review the recent evidence behind the association of low levels (ie, below the fifth percentile) of pregnancy-associated plasma protein A (PAPP-A) with adverse perinatal outcomes and to integrate new findings with the recommendations made by the Society of Obstetricians and Gynaecologists of Canada in 2008. QUALITY OF EVIDENCE A review of recently published articles revealed that...

Placental function in multifetal pregnancies before and after embryo reduction was investigated by measuring maternal serum concentrations of pregnancy associated placental protein-A (PAPP-A) and pregnancy specific beta-1-glycoprotein (SP-1). Three groups of pregnant women were studied following assisted reproduction; groups 1 and 2, were 12 singleton and 12 twin pregnancies respectively, and g...

We enrolled 151 healthy mother/newborn couples and 26 with gestational diabetes mellitus (GDM). HLA-G and PAPP-A plasma levels were measured by ELISA at first and second trimesters, at delivery, and in cord blood. HLA-G 14 bp ins/del and PAPP-A A/C polymorphisms were genotyped. HLA-G del/del and PAPP-A C/C genotypes were more frequent among GDM mothers than controls. We observed a genetic epist...

BACKGROUND Determination of oocyte fertilization and embryo quality are one of the most important purposes in ART cycles. Follicular fluid provides an important microenvironment for development of oocytes and some biochemical characteristics of the follicular fluid, such as pregnancy-associated plasma protein-A (PAPP-A), may play an important role in prediction of success rate of ART. OBJECTI...

s: Takács Sz, Bankó S, Nagymajtényi L, Papp A (2009) Acute and subacute functional neurotoxicity of manganese in rats. FEPS 2009, Ljubljana, Szlovénia, 2009. november 12-15. Book of Abstracts p. 254. Takács Sz, Papp A (2010) Changes of cortical electrical activity and open field motility in WAG rats during several weeks of oral manganese exposure. IBRO International Workshop 2010, Pécs, 2010. j...