Paraquat can cause oxidative stress through redox cycling, and preimplantation embryos are sensitive to oxidative stress in vitro. In this study, the effects of paraquat on preimplantation embryo development were examined. Exposure of preimplantation embryos (collected on the day after ovulation) to paraquat in vitro for 24 h at concentrations as low as 8 microM caused a significant decrease in...

may be present long before they are clinically apparent. Classically, pulmonary complications become apparent only about a week after paraquat ingestion, but lesions are regularly apparent in animals long before this. At present, it is still not clear from our data whether the airway epithelium is involved or not and we are studying the matter further. As noted, rather nonspecific alterations w...

BACKGROUND Paraquat poisoning is well known for causing multiple organ function failure (MODS) and high mortality. Acute lung injury and advanced pulmonary fibrosis are the most serious complications. Bosentan is a dual endothelin receptor antagonist. It plays an important role in treating PF. There is no related literature on the use of bosentan therapy for paraquat poisoning. OBJECTIVE To s...

The most important step for Paraquat analysis in post-mortem human blood (PMB) is its extraction from the specimens, as Paraquat is insoluble in organic solvents due to its ionic form. The most common extraction method, solid phase extraction (SPE), has been used for the extraction of Paraquat from PMB. However, SPE procedures are somewhat time-consuming, and resulted in unsatisfactory recovery...

Soybean (Glycine max.) is one of the most important legumes cultivated worldwide. Its productivity can be altered by some biotic and abiotic stresses like global warming, soil metal pollution or over-application herbicides paraquat (1,1’-dimethyl-4,4’-bipyridinium dichloride). In this study, effect oxidative stress produced addition (0, 20, 50 100 µM) during plant growth on symbiotic nitrogen f...

Pulmonary lesions following paraquat poisoning are believed to be almost invariably fatal. The three patients reports here survived despite persistent radiological change. One of the patients died after taking a larger dose of paraquat one year later, and at necropsy histological changes attributable to the two episodes of paraquat poisoning were apparent.

A few species have evolved resistance to paraquat after repeated selection. As paraquat still inhibited N A D P reduction, we hypothesized that resistance might be due to (a) detoxification o f the paraquat-generated active oxygen species and (b) that resistant plants would have some cross resistance to other xenobiotic oxidants as well as to photoinhibition, which we subse­ quently demonstrate...

The effects of the herbicide Paraquat were investigated in honey bee larvae with attention focused on oenocytes. Honey bee larvae were exposed to Paraquat at different concentrations in the food: 0, 0.001, 0.01, 0.1 and 1 µg/kg. In controls, between 24 h and 48 h, oenocytes grew from 630.1 to 1643.8 µm(2) while nuclei changed in size from 124.9 to 245.6 µm(2). At 24 h, Paraquat induced a slight...