Background: Obesity seems to be a critical issue nowadays because of its high prevalence and adverse effects on health. There is some evidence indicating the relationship between obesity lower serum 25- hydroxyvitamin D concentration. Objectives: The objectives this study were assess vitamin status estimate response in obese non-obese children after supplementation. Methods: This was Quasi expe...

New data concerning the function of osteocytes as the central regulators of bone homeostasis are briefly outlined. It is established that osteocytes are the main target cells for parathormone. They are a rich source of sclerostin, the main inhibitor of osteoblast activity, and of the RANKL cytokine, the most important regulator of osteoclastogenesis. Under shear stress causing microinjury, oste...

To the editor: In recent decades it has been shown that parathyroid hormone could influence haematopoiesis through a direct action on haematopoietic precursors: at low concentration, parathormone could stimulate haematopoiesis and, in contrast, would be inhibitory at high concentration. Furthermore, about 10 cases of polycythaemia associated with hyperparathyroidism have been reported (1-8). We...

Calciphylaxis is a lethal disorder seen in patients with end-stage renal disease and is characterized by painful necrotic skin lesions. The pathophysiology is still unknown. Elevated calcium, phosphorous and parathormone appear to play a role in causing small and medium sized vasculopathy. Diagnosis is delayed, prognosis is poor and mortality remains high. In this article we describe the case o...

INTRODUCTION Chronic renal failure is associated with endocrine abnormalities, which in some cases cause polyendocrinopathy responsible for the symptoms and complications. The consequence of secondary hyperparathyroidism is not only bone disease but may be cardiovascular disorders, peripheral nerve damage and impact on the level of sex hormones. THE AIM To evaluate the interactions between pa...

Pseudohypoparathyroidism is a rare inherited metabolic disorder that associated with parathormone resistance. Low serum calcium, high phosphates and raised levels suggesting resistance are biochemical characteristic features of . type 1 known as Albright’s hereditary osteodystrophy characterized by typical phenotype. This syndrome encompasses multiple clinical findings such brachydactyly, round...