Clinical or subclinical hyperparathyroidism is one of the most common endocrine disorders. Excessive secretion of parathyroid hormone is most frequently caused by an adenoma of >or=1 parathyroid gland. Unsuccessful surgery with persistent hyperparathyroidism, due to inadequate preoperative or intraoperative localization, may be observed in about 10% of patients. The conventional surgical approa...

OBJECTIVE Dual-phase (99m)Tc-sestamibi (methoxyisobutylisonitrile [MIBI]) imaging is the technique of choice for hyperparathyroidism (HPT), especially for localizing parathyroid adenomas. Prior studies have shown its utility for detecting hyperplasia is equivocal, but we believe this is not true. We attempted to quantitate the region-of-interest counts per pixel between immediate images and del...

Primary Hyperparathyroidism is known to present with protean manifestations leading to misdiagnosis in the initial stages of the disease. Inability to locate the adenoma in an ectopic parathyroid gland may further delay the diagnosis of these cases. Aberrant migration during development may lead to intrathyroidal or other ectopic locations of parathyroid glands. This may lead to their misdiagno...

Novel surgical applications include radioguided procedures in parathyroidectomy operations. In order to investigate the feasibility of usage of the portable gamma camera in parathyroidectomy operations; intraoperative radioguided parathyroidectomy operation was performed in three hyperparathyroidism patients with inconclusive preoperative parathyroid scintigraphy results. Intraoperative portabl...

Introduction. Primary hyperparathyroidism is rare pathology in children (2?5:100,000). In more than 85% of patients, a single adenoma present, and its extirpation usually the only treatment patient requires. approximately 15?80% cases, ectopic mediastinal parathyroid tissue can be found inside thymus. Case outline. Our was 13-year-old boy, who presented with multiple bone fractures previous per...

There are many imaging modalities available for studying thyroid and parathyroid masses. For the thyroid gland, the demonstration of a hyperfunctioning or purely cystic mass by scintigraphy and ultrasound reassures that a palpable nodule is not cancer. Solitary, cold, or solid nodules often requires biopsy because of suspicion of malignancy. Metabolic and inflammatory disorders are imaged best ...

UNLABELLED Double-phase single-tracer scintigraphy with (99m)Tc-sestamibi is now generally used for parathyroid imaging but, at least in endemic goiter areas, complementary thyroid scintigraphy is recommended. Although (123)I-sodium iodide is considered to be the optimal thyroid agent, it is hardly ever used because of high costs and logistic difficulties. Our study presents the results of usin...

INTRODUCTION Parathyroid crisis due to ectopic parathyroid adenomas can pose diagnostic and management challenges, since it is quite rare in clinical practice. CLINICAL FINDINGS/PATIENT CONCERNS A 67-year-old Chinese male presented as a parathyroid crisis due to an ectopic mediastinal parathyroid adenoma with his serum calcium and PTH markedly increased in short time. An ultrasonography and c...

background: bilateral neck exploration is the gold standard for parathyroid adenoma localization in primary hyperparathyroidism. but surgeons do not have adequate experience for accurate surgical exploration and new methods are developed for surgery like unilateral exploration and minimally invasive surgery, thus, preoperative localization could reduces time and stress in surgical performance. ...

V a r i o u s imaging methods have been used for the preoperative localization of parathyroid tumors in patients with hyperparathyroidism. Among the noninvasive methods, several scintigraphic techniques have been employed, including variations on the dual-isotope 2°ITI/99mTC subtraction techniques (1-3). Modification of this technique, using 123I instead of [99mTC] pertechnetate, has also been ...