Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects different from those of cocaine. One hypothesis is that muscarinic-M(1) receptor actions interfere with cocaine-like effects. Several tropane-nitrogen substitutions of 4',4"-diF-BZT have reduced M(1) affinity compared ...

dam reservoirs supply potable, agricultural, and industrial water in most cities of iran. due to lack of proper operational rules or unbalanced demand versus water resources volume, (along operating time) correction in operational rules is required to fulfill current situations. hence the goal of this study is to optimize the qeshlaq dam reservoir operation rules to maximize the water release f...

agricultural crops and food materials exert frictional forces on agricultural machinery elements and on storage walls during their harvest, transportation, processing and storage. coefficient of friction is an important parameter to be predetermined in designing equipments and evaluating processes. an assessment of the coefficient of friction for agricultural materials is usually done through s...

A thermohydrodynamic (THD) analysis of turbulent flow in journal bearings is presented based on the computational fluid dynamic (CFD) techniques. The bearing has infinite length and operates under incompressible and steady conditions. In this analysis, the numerical solution of Navier-Stokes equations with the equations governing the kinetic energy of turbulence and the dissipation rate, couple...

The influence of dehydrocholate on bromsulphthalein relative-storage capacity, biliary transport maximum (Tm), and fractional transfer rates between plasma, liver, and bile have been studied in unanaesthetized dogs. In six dogs, storage capacity, Tm, and fractional transfer rates from plasma to liver, liver to bile, and liver to plasma were measured during 0-15 M NaCl infusion and the measureme...

Event tracing provides the detailed data needed to understand the dynamics of interactionsamong applicationresourcedemands and system responses. However, capturingthe large volume of dynamic performance data inherent in detailed tracing can perturb program execution and stress secondary storage systems. Moreover, it can overwhelm a user or performance analyst with potentially irrelevant data. U...

BACKGROUND Previous in vivo data suggest that high airway resistance (R(aw)) promotes dynamic hyperinflation, especially when coupled to high minute ventilation (V(E)). However, no studies have systematically examined the relative effects of various mechanical parameters on dynamic hyperinflation. METHODS Intrinsic positive end-expiratory pressure (PEEPi) was measured with a ventilator-lung m...