BACKGROUND Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in diabetes, wherein it also ameliorates left-ventricular (LV) hypertrophy. However, direct in vivo evidence that trientine can improve cardiac function in heart failure has hithe...

BACKGROUND Digital image analysis (DIA) enables better reproducibility of immunohistochemistry (IHC) studies. Nevertheless, accuracy of the DIA methods needs to be ensured, demanding production of reference data sets. We have reported on methodology to calibrate DIA for Ki67 IHC in breast cancer tissue based on reference data obtained by stereology grid count. To produce the reference data more...

The mammalian embryo develops as a quasi-stem cell system whose differentiation and pluripotentiality in vitro is controlled by a single regulatory factor, Differentiation Inhibiting Activity/Leukemia Inhibitory Factor (DIA/LIF). DIA/LIF is expressed in two distinct functional forms, derived from the use of alternate transcriptional start sites, one of which is freely diffusible and the other t...

In this work we propose a new automatic image annotation model, dubbed diverse and distinct image annotation (DIA). The generative model DIA is inspired by the ensemble of human annotations, which create semantically relevant, yet distinct and diverse tags. In DIA, we generate a relevant and distinct tag subset, in which the tags are relevant to the image contents and semantically distinct to e...

Resistance to the anabolic effects of growth hormone (GH) occurs with severe caloric deficit. This study examined whether moderate caloric deficit (50% of daily intake for 7 days) in the adolescent rat exceeds a critical threshold for GH action and whether a combination of GH and insulin-like growth factor I (IGF-I) would have enhanced anabolic effects on the diaphragm (Dia). Five groups of rat...

UNLABELLED INTRODUCTION AND CASE DESCRIPTION: Desmoplastic infantile astrocytomas (DIA) are rare intracranial tumors of infancy with distinctive clinical and radiological features. Despite their radiologically aggressive appearance they tend to follow a benign course with favorable prognosis even after subtotal resections. Non-infantile cases are rarely encountered with only four cases reported...

The bulbs of Allium sativum (ASE) and leaves of Lagerstroemia speciosa (LSE) are traditionally used to treat a variety of health disorders in the southern part of India. DIA-2 is a herbal formulation developed to contain fixed ratio (1:1 w/w) of ASE and LSE. In the present study, the phytochemical analysis of ASE and LSE was carried out following standard protocols. Also, a simple, rapid and re...

The effects of muscle contractions on the profile of postcontraction resting intracellular Ca2+ ([Ca2+]i) accumulation in Type 1 diabetes are unclear. We tested the hypothesis that, following repeated bouts of muscle contractions, the rise in resting [Ca2+]i evident in healthy rats would be increased in diabetic rats and that these changes would be associated with a decreased cytoplasmic Ca2+ -...

The performance of DIA methods was influenced by the number of DIA windows, the scan resolution, the gradient length and the sampling of the chromatographic peaks. Additionally, the MS1 scan of the DIA method had an important influence on the performance. To optimize quantification on MS1, we evaluated the following conditions. We established a comprehensive spectral library by measuring tripli...