OBJECTIVES Limited information is available concerning the post-treatment neutrophil-lymphocyte ratio in critical limb ischemia patients who receive conservative therapy. Accordingly, this study was designed to evaluate the predictive value of the post-treatment neutrophil-lymphocyte ratio in critical limb ischemia patients without surgery. METHOD From January 2009 to January 2011, critical l...

Aim: to evaluate the dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) depending on ejection fraction left ventricular (LV). Material and methods. The study group consisted 23 consecutive STEMI admitted Regional Clinical Cardiology Center Chernivtsi, who underwent successful reperfusion treatment...

Abstract Tuberculosis (TB) recurrence following drug treatment and apparent clinical cure affects an estimated 700,000 people annually is increasingly associated with relapse of initial Mycobacterium tuberculosis (Mtb) infection. Cellular immunity by T helper (Th) cells, including Th17 populations important during active TB. The contribution other Th to immune pressure Mtb clearance TB chemothe...

OBJECTIVE This study aimed to evaluate the efficacy of PLI and results of subsequent pregnancy in women with RM showing alloimmune response. MATERIALS AND METHODS Immunological investigations were performed in patients with RM. Subsequently, PLI was administered to 241 patients at their request. Of these, 202 conceived between September 2005 and September 2012. RESULTS Of the 202 women, 169...

BACKGROUND Although antiretroviral therapy (ART) has proven its success against HIV-1, the long lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 strains in naïve, central memory and effector memory CD4+ lymphocyte subsets. METHODS From five patients cellular HIV-1 infection levels were quantified before and after initi...

BACKGROUND Large granular lymphocyte leukemia is a rare lymphoproliferative disorder associated with autoimmune diseases and impaired hematopoiesis. This study describes the clinical and biological characteristics of 229 patients with T-cell or NK-cell large granular lymphocyte leukemia. DESIGN AND METHODS The diagnosis was based on a large granular lymphocyte expansion (> 0.5x10(9)/L) lastin...

Purpose: Approximately half of rectal cancer cases are diagnosed at a locally advanced stage. It is important to identify biomarkers that can predict pathological complete response in patients undergoing surgery following neoadjuvant chemoradiotherapy.
 Materials and Methods: This retrospective study included 205 with who underwent adjuvant chemotherapy chemoradiotherapy. Inflammatory were...

Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate maternal immune responses during pregnancy, in order to make uterus an immune privileged ...