نتایج جستجو برای: pathogenicity island

تعداد نتایج: 72467  

2005
Sarah Keates Andrew C. Keates Sheuli Nath Richard M. Peek Ciarán P. Kelly

Abbreviations: Egr-1, early growth response gene-1; EGFR, epidermal growth factor receptor; ERK, extracellular-regulated kinases; MAP kinases, mitogen-activated protein kinases; PAI, pathogenicity island; cag, cytotoxin associated genes; PMA, Phorbol-12myristate-13-acetate; MOI, Multiplicity of infection; GAPDH, glyceraldehyde-3phosphate dehydrogenase; PCR, polymerase chain reaction; PBS, phosp...

Journal: :Cellular microbiology 2008
Roman G Gerlach Nuno Cláudio Manfred Rohde Daniela Jäckel Carolin Wagner Michael Hensel

Invasion is an important microbial virulence strategy to overcome the barrier formed by polarized epithelial cells. Salmonella enterica is a food-borne pathogen that deploys a type III secretion system for the manipulation of the actin cytoskeleton and to trigger internalization into epithelial cells. Here we show that this function is not sufficient to enter polarized cells and report that pen...

Journal: :journal of medical bacteriology 0
mohammadsadegh madadi department of clinical sciences, faculty of veterinary medicine, university of tabriz, tabriz, ir iran. sara mirzaie department of animal, poultry and aquatic sciences, institute for agricultural research, iranian organization for science and technology, tehran, ir iran. mohammad hassanzadeh department of poultry diseases, faculty of veterinary medicine, university of tehran , ir iran.

background : salmonella actively stimulates its own uptake into the epithelial cells by inducing cytoskeleton rearrangements and membrane ruffling triggered by some proteins secreted by salmonella into the cytosol of the epithelial cells via a type iii secretion system (ttss) encoded by genes of the salmonella pathogenicity island 1 (spi-1). hila is a transcriptional activator encoded on salmon...

Journal: :Journal of bacteriology 2004
Igor N Olekhnovich Robert J Kadner

Expression of invasion genes in Salmonella pathogenicity island 1 (SPI-1) is mainly driven by the transcriptional activator HilA. Transcription of hilA is subject to complex control and is stimulated by the SPI-1-encoded HilC and HilD proteins. The C-terminal domain of RpoA contributes to hilA activation by HilC/D under certain inducing conditions.

Journal: :New microbes and new infections 2015
C Gallois C Hauw-Berlemont C Richaud S Bonacorsi J-L Diehl J-L Mainardi

We report a fatal case of necrotizing soft tissues infection caused by an Escherichia coli strain belonging to phylogenetic group C and harbouring numerous virulence factors reported to be part of a pathogenicity island (PAI) such as PAI IIJ96 and conserved virulence plasmidic region.

Journal: :Science 1999
A Covacci J L Telford G Del Giudice J Parsonnet R Rappuoli

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests c...

2016
Eduardo Mucito-Varela Gonzalo Castillo-Rojas Miguel A Cevallos Luis Lozano Enrique Merino Gamaliel López-Leal Yolanda López-Vidal

Helicobacter pylori-induced gastritis is a risk factor for developing gastric pathologies. Here, we report the complete genome sequence of a multidrug-resistant H. pylori strain isolated from a chronic gastritis patient in Mexico City, Mexico. Nonvirulent VacA and cag-pathogenicity island (PAI) genotypes were found, but the presence of a potential mobilizable plasmid carrying an IS605 element i...

Journal: :Journal of clinical microbiology 2010
Mônica A M Vieira Fábia A Salvador Rosa M Silva Kinue Irino Tânia M I Vaz Anna C Rockstroh Beatriz E C Guth Tânia A T Gomes

The presence of the pathogenicity island (PAI) O122 genes, efa1 (lifA), sen, pagC, nleB, and nleE, in typical and atypical enteropathogenic Escherichia coli (EPEC) strains was investigated. The simultaneous occurrence of all genes was statistically associated with diarrhea due to atypical EPEC. Detection of the complete PAI O122 could aid in the identification of potential pathogenic strains of...

Journal: :Journal of bacteriology 2008
Tomohiko Sugiyama Tetsuya Iida Kaori Izutsu Kwon-Sam Park Takeshi Honda

In this study, we determined the borders of the pathogenicity island in V. parahaemolyticus RIMD2210633 (Vp-PAI). Vp-PAI has features in common with Tn7 and other related elements at both terminal ends. Our findings indicate that the mobile element with a transposase which contains the DDE motif may have been involved in Vp-PAI formation.

Journal: :Journal of bacteriology 2001
C P Lostroh C A Lee

Salmonella pathogenicity island 1 (SPI1) encodes a type III secretion system that is required for virulence during the intestinal phase of infection. The expression of SPI1 genes is controlled by many global regulatory pathways that affect the expression/activity of transcriptional regulators encoded on SPI1.

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