Chronic and acute extracorporeal detoxification treatments, such as haemodialysis, haemofiltration, haemodiafiltration or haemoperfusion, clearly have become parts of the standard armamentarium of modern medicine. The necessary technical equipment has been transformed in the course of the last decades from prototype-like monsters (which nobody dared to touch without thorough education) to handy...

Upon initial examination, efforts toward achieving these 2 goals appear philosophically complementary. For example, both tout as a primary benefit improvement of access to health care services. However, closer inspection of these initiatives' more prominent features reveals seemingly irreconcilable demands. As described below, the push toward consumer-driven health plans as a way to offer affor...

Metformin is a biguanide, insulin sensitiser that reduces blood sugar levels. There are concerns about the risk of lactic acidosis in patients receiving metformin who have procedures requiring iodinated contrast, and in those with renal impairment or heart failure. The data on which these concerns are based are reviewed, with the conclusion that metformin treatment is rarely to blame for lactic...

Background: Lennox-Gastaut syndrome (LGS) is an epileptic encephalopathy, characterized by drug-resistant multiple seizure types. The aim of this study was to determine if the adjunctive use of electroconvulsive therapy (ECT) in patients with LGS and drug-resistant epilepsy is efficacious in decreasing their seizure frequency and also to investigate its safety and tolerability.   Method...

background: bleeding events in hemophilic patients with inhibitors are managed by bypassing agents. currently available agents in iran are recombinant activated factor vii (rfviia; aryogen, aryoseven) and feiba (factor eight inhibitor bypassing agent). no standardized and accurate assay is currently available for monitoring the effectiveness of bypassing agents. we suggested that history of the...

thrombolytic therapy, an appropriate treatment option , if primary angioplasty is not available for the treatment of Acute Myocardial Infarction patients in the early hours after the onset of the symptoms. The aim of this study was to evaluate the safety and effectiveness of the tenecteplase drug vs alteplase  in the treatment of STEMI patients. We searched the PubMed, cochrane library, Web Of ...

introduction: basal cell carcinoma (bcc) is the most common cutaneous malignancy. proffered treatment for these lesions is surgery. based on patient’s age, drug allergies, and place of lesions, surgery may not be the best option, and alternative treatments should be considered. pulsed dye laser (pdl) may be a good alternative therapy. the aim of the present study was to determine the effectiven...

conclusions intravenous paracetamol is an effective and safe treatment for patients admitted to the emergency department with headaches caused by head trauma. patients and methods this study was a single-center, prospective, randomized, double-blind clinical trial conducted on two groups treated with intravenous paracetamol and intravenous morphine. thirty patients were enrolled in each group. ...

Preliminary work on the development of measures appropriate for the safety domain is reported. Measures are expressed in the style of the Practical Software and Systems Measurement (PSM) approach, a programme sponsored by the US DoD. Proposed measures are integrated with the PSM measurement framework. Reported work has been informed by discussions within the PSM community and by concurrent work...