Purpose The UK's purpose-built student accommodation (PBSA) sector has seen significant institutional investment in recent decades. This paper unpacks contemporary trends and perspectives on the sector. It questions whether PBSA moved from being an “alternative” to “mainstream” residential asset class, framing analysis through lens of market maturity. Design/methodology/approach methods triangu...

Background Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and Apolipoprotein E (ApoE) are two of the strongest genetic risk factors for late-onset Alzheimer’s disease (AD), but while their interplay in microglial response to AD pathology is hotly studied, surprisingly little known about mechanism by which variants impair this role. Method To define structural AD-associated TREM2-ApoE ...

Solubility of carbon dioxide in poly(vinyl acetate) (PVAc), poly(2,6-dimethyl-1,4-phenylene ether) (PPO), polypropylene (PP), and high-density polyethylene (HDPE), poly(butylene succinate) (PBS), poly(butylene succinate-co-adipate) (PBSA) and polystyrene (PS) are modeled by adaptive neuro-fuzzy inference system (ANFIS) in wide range of pressure and temperature. The results obtained in this work...

The effects on tubulin dynamics of paclitaxel, ortataxel and two recently developed taxol derivatives bearing a five-membered heterocyclic ring fused at the 1,14 position were analysed by means of molecular dynamic simulations and the MM-PBSA approach. Tubulin polymerization kinetics and microtubule morphology assays were also conducted, providing support to computational results. In particular...

Despite the contemporary advancements in field of science and medicine, combating coronavirus disease 2019 (COVID-19) is extremely challenging many aspects as virus keeps spreading mutating rapidly. As there no effective conclusive drug therapy to date, it crucial explore plant-based natural compounds for their potential inhibit SARS-CoV-2 (severe acute respiratory syndrome 2). Recent research ...

Endo-1,4-β-xylanase (EC 3.2.1.8) is the enzyme from Ruminococcus albus 8 (R. albus 8) (Xyn10A), and catalyzes the degradation of arabinoxylan, which is a major cell wall non-starch polysaccharide of cereals. The crystallographic structure of Xyn10A is still unknown. For this reason, we report a computer-assisted homology study conducted to build its three-dimensional structure based on the know...

The calcium-dependent lectin I from Pseudomonas aeruginosa (PA-IL) binds specifically to oligosaccharides presenting an -galactose residue at their non-reducing end, such as the disaccharides Gal1-2GalOMe, Gal1-3GalOMe and Gal1-4GalOMe. This provides a unique model for studying the effect of the glycosidic linkage of the ligands on structure and thermodynamics of the complexes by means o...

The epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase family that plays a role in multiple cellular processes. Activation of EGFR requires binding of a ligand on the extracellular domain to promote conformational changes leading to dimerization and transphosphorylation of intracellular kinase domains. Seven ligands are known to bind EGFR with affinities ranging...