The study investigates the effect of polycaprolactone (PCL) concentration on metformin hydrochloride (MH) release ratio electrospun nanofiber scaffolds. Blend and emulsion electrospinning are used to produce performance nanofibrous scaffolds was evaluated by morphology (Field Emission Scanning Electron Microscopy, FESEM), chemical (Fourier Transform Infrared Spectroscopy, FTIR), thermal (Differ...

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

Mimicking one or more components of the basement membrane (BM) holds great promise for overcoming insufficiencies in tissue engineering therapies. We have electrospun laminin nanofibers (NFs) isolated from the murine Engelbreth-Holm Swarm (EHS) tumor and evaluated them as a scaffold for embryonic stem cell culture. Seeded human embryonic stem cells were found to better maintain their undifferen...

OBJECTIVE The development of combining mesenchymal stem cells (MSCs) with surface modified three-dimensional (3D) biomaterial scaffold provides a desirable alternative for replacement of damaged and diseased tissue. Nanofibrous scaffolds serve as suitable environment for cell attachment and proliferation due to their similarity to the physical dimension of the natural extracellular matrix. In t...

background: development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. methods: plla/pcl aligned fibrous scaffold was fabricated using electrospinning method. adscs...

The objective of this research was to develop an environment-friendly and scalable method for the production self-sanitizing electrospun nanofibers. This achieved by immobilizing silver nanoparticles (Ag NPs) onto plasma-treated surfaces biodegradable polycaprolactone (PCL) plasma deposited polymer layer containing carboxyl groups played a critical role in providing uniform distribution Ag NPs ...

introduction: the native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. considering the suitable characteristics of induced pluripotent stem cells (ipscs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (de...