Temperature-dependent interplane resistivity ρc(T ) was measured systematically as a function of transitionmetal substitution in the iron-arsenide superconductors Ba(Fe1−xMx)2As2, M = Ni, Pd, Rh. The data are compared with the behavior found in Ba(Fe1−xCox)2As2, revealing resistive signatures of pseudogap. In all compounds we find resistivity crossover at a characteristic pseudogap temperature ...

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are linked, but the phosphosubstrate that connects LRRK2 kinase activity to neurodegeneration is not known. Here, we show that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD model...

Pathogenic mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant and certain cases of sporadic Parkinson's disease (PD). The G2019S substitution in LRRK2 is the most common genetic determinant of PD identified so far, and maps to a specific region of the kinase domain called the activation segment. Here, we show that autophosphorylation of LRRK2 is an intermolecula...

The title compound, [Pd(C(12)H(10)ClN(2)O(2))Cl(C(18)H(15)P)(2)], is the inter-mediate of the reduction of a 3,5-dichloro-pyrazinone [Loosen, Tutonda, Khorasani, Compernolle & Hoornaert (1991 ▶). Tetra-hedron, 47, 9259-9268]. This species is formed by oxidative addition of coordinatively unsaturated Pd(0) to the reactive 3-position of the heterocycle. The coordination around the Pd atom is squa...

IR spectroscopic and X-ray structural data of rhodium and palladium complexes of N-heterocyclic carbene (NHC) and 1H-pyridin-(2E)-ylidene (PYE) ligands indicate that both ligand classes exhibit similar electron-donating properties. However, catalytic application of palladium PYE complexes appears to be limited by PYE ligand loss. Density functional theory (DFT) calculations show that the Pd–CNH...

BACKGROUND To date, 5 well-confirmed genes for Parkinson disease (PD) have been identified, including 3 autosomal recessive genes: PTEN-induced putative kinase 1 (PINK1), parkin, and DJ-1. Almost nothing is known about the genetics of PD in Saudi Arabia; however, consanguineous families, not infrequent in this population, could be important in the evaluation of known PD genes and the search for...

Graphene-supported (40-x) wt% Pd x wt% Co (0≤x≤13.33) alloys/composites have been prepared by a microwave-assisted polyol reduction method and been investigated for their structural and electrocatalytic properties for the oxygen reduction reaction (ORR) in 0.5 M H2SO4 at 298 K. The study demonstrated that the bimetallic Pd-Co composite nanoparticles are, in fact, alloy nanoparticles with fcc cr...

BACKGROUND Paroxysmal dyskinesias (PDs), a clinically and genetically heterogeneous group of episodic movement disorders, include kinesigenic PD (PKD), exercise-induced PD (PED) and non-kinesigenic PD (PNKD). These disorders are all transmitted as autosomal dominant traits with incomplete penetrance. Several PD-related genetic disorders, including PKD and familial infantile convulsions with par...

a palladium composite membrane was prepared via electroless plating technique using organic-inorganic method during activation process. the ceramic support surface was modified by two tio2-boehmite and one γ-alumina layers to avoid pd penetration in support pores. thin and defect-free pd composite membrane was obtained by creating a relative smoothness on the ceramic support and using pd nanopa...

BACKGROUND The anticancer properties of cisplatin and palladium(II) complexes stem from the ability of the cis-MCl2 fragment to bind to DNA bases. However, cisplatin also interacts with non-cancer cells, mainly through bonding molecules containing -SH groups, resulting in nephrotoxicity. This has aroused interest in the design of palladium(II) complexes of improved activity and lower toxicity. ...