Although with a standardized incidence of 0.54 cases per 100,000 persons, differentiated thyroid cancer (DTC) is a rare disease in children and adolescents, it nonetheless concerns ~1.4% of all pediatric malignancies. Furthermore, its incidence is rising. Due to the rarity and long survival of pediatric DTC patients, in most areas of treatment little evidence exists. Treatment of pediatric DTC ...

In 1971 president Richard Nixon declared a war on cancer and announced his goal to cure cancer by 1976, the bicentennial year. Thirty nine years and more than 100 billion dollars later, the cumulative adult death rate from cancer adjusted for the size and age of the population has improved by less than 5% [1]. In comparison, the death rate for heart disease over this time period has improved by...

Background Cancer survivorship is frequently associated with severe late effects. However, research into pediatric cancer survivors on effects in motor ability, physical self-concept and their relationship to quality of life limited. Methods Using multiple regression analyses, 78 56 typically developing children were compared health-related life. In addition, mediational multi-group analyses be...

In 1971 president Richard Nixon declared a war on cancer and announced his goal to cure cancer by 1976, the bicentennial year. Thirty nine years and more than 100 billion dollars later, the cumulative adult death rate from cancer adjusted for the size and age of the population has improved by less than 5% [1]. In comparison, the death rate for heart disease over this time period has improved by...

OBJECTIVES To describe selected components of pediatric palliative care from diagnosis to cure or end of life that combine to help nurses and other clinicians achieve goals of care for children with cancer and their families. DATA SOURCES Published articles. CONCLUSION Pediatric palliative care is characterized by diversity of care delivery models; effect of cancer on the family as the cent...

Childhood cancers are life-threatening diseases that are universally distressing and potentially traumatic for children and their families at diagnosis, during treatment, and beyond. Dramatic improvements in survival have occurred as a result of increasingly aggressive multimodal therapies delivered in the context of clinical research trials. Nonetheless, cancers remain a leading cause of death...

BACKGROUND & AIMS Malnutrition is a serious concern for children with cancer and nutrition screening may offer a simple alternative to nutrition assessment for identifying children with cancer who are at risk of malnutrition. The present paper aimed to evaluate the nutrition screening tool for childhood cancer (SCAN). METHODS SCAN was developed after an extensive review of currently available...

Pediatric tumors are relatively infrequent, but are often associated with significant lethality and lifelong morbidity. A major goal of pediatric cancer research has been to identify key drivers of tumorigenesis to eventually develop targeted therapies to enhance cure rate and minimize acute and long-term toxic effects. Here, we used genomic approaches to identify biomarkers and candidate drive...

The prevalence of childhood cancer attributable to genetic predisposition was generally considered very low. However, recent reports suggest that at least 10% of pediatric cancer patients harbor a germline mutation in a cancer predisposition gene. Although some of these children will have a family history suggestive of a cancer predisposition syndrome, many others will not. Evidence from recent...