Hydrogen peroxide (H(2)O(2)) is a strong oxidant that induces apoptosis of tumor cells in vitro. Here, we investigated the antitumor activity of an H(2)O(2)-generating enzyme, D-amino acid oxidase (DAO), and its conjugate with polyethylene glycol (PEG; PEG-DAO). Compared with DAO, PEG-DAO showed improved pharmacokinetic parameters in mice after i.v. injection. PEG-DAO administered i.v. accumula...

The objective of the present study was to evaluate the effect of different plasticizers on the ethylcellulose coatings of capsules and its timed release characteristics. Various plasticizers such as dibutyl phthalate (DBP), triacetin (TA), glycerol, triethyl citrate (TEC), polyethylene glycol-4000 and polyethylene glycol-6000 (PEG) were studied. The physicochemical properties of the casted poly...

Use of cytokines as biomarkers for disease is getting more widespread. Cytokines are conveniently determined by immunoassay, but interference from present antibodies is known to cause problems. In rheumatoid arthritis (RA), interference of rheumatoid factor (RF) may be problematic. RF covers a group of autoantibodies from immunoglobulin subclasses and is present in 65-80% of RA patients. Partly...

Drought is one of the major environmental problems in agricultural field worldwide. The present study investigated the effects of water deficit caused by exogenous application of polyethylene glycol (PEG) on cabbage (Brassica oleracea var. capitata) grown in hydroponic culture. Root length, shoot length, dry weight, and relative water content of the seedlings significantly decreased in dose dep...

Abstract Purpose To prepare stable sustained-release (SR) pellets, containing high ibuprofen (IBU) loading, by hot-melt extrusion (HME) technique using polyethylene glycol 6000 (PEG 6000) and glyceryl monostearate (GMS). Methods HME pellets (60% w/w IBU) were prepared PEG 6000, GMS, mixture of both polymers (1:1). Stability studies performed under stress conditions (40 °C relative humidity “RH”...

Objective: The aim of the present study was to develop and evaluate the monolithic osmotic tablet (MOT) composed of the solid dispersion of ketoprofen (KETO), a poorly water-soluble drug. Solid dispersion technique is generally used for immediate release, as this maximizes the amount of drug absorbed. Sustained release may be obtained by combining solid dispersion technique with MOT so as to in...

Introduction: The Papuan people have utilized the native herb Laportea decumana (Roxb.) Wedd for centuries to treat aches and pains L. is used by attaching leaves to the body area with illness. Methods: This study aimed test optimal composition of PEG 400 and 6000 in L.decumana  simplicia ointment formula produce a good ...

In a series of experiment, the response of two contrasting potato species, namely,  Solanum acaule (tolerant) and Solanum tuberosum cv. Agria (intolerant) to salt (80 mM NaCl) and drought stress (15% polyethylene glycol;PEG) was studied in vitro. Furthermore, the role of acetyl salicylic acid (ASA) (1 and 10 µM) in alleviating oxidative stress was investigated. In Agria cultivar, NaCl and PEG r...

The Leuconostoc species require sucrose in the culture medium as an inducer for the elaboration of glucosyltransferase (GTF) and glucans. Among all the reported putification methods, polyethylene glycol (PEG) is a effective and single step purification method for GTF from Leuconostoc mesenteroides. The extracellular GTFs from Leuconostoc mesenteroides L.m.28 and mutant Leuconostoc mesenteroides...

The effect of salt and drought stress at the water potentials of-2, -4,-6and -8 bars induced by NaCl and PEG 6000 (Polyethylene glycol 6000) each, on germination and early seedling growth, were investigated for two varieties (PU-19 and Type-9). Electrical conductivity (EC) value of the NaCl solutions were 4.5, 8.8, 12.7 and 16.3 dS m(-1). Germination percentage, root and shoot length, and seedl...