نتایج جستجو برای: pemphigus vulgaris
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indirect immunofluorescence (iif) has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by iif have been conflicting. we conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on pemphigus area and a...
INTRODUCTION Pemphigus vulgaris is a rare cause of oral mucosal ulceration. CLINICAL PICTURE A 47-year-old Chinese man presented with a 3-month history of oral ulceration. There were no lesions on the skin or other mucosal sites. Histology and immunostaining were consistent with pemphigus vulgaris. TREATMENT Systemic and topical corticosteroids were instituted, together with topical antifun...
Citation: Seiffert-Sinha K, Khan S, Attwood K, Gerlach JA and Sinha AA (2018) Anti-Thyroid Peroxidase Reactivity Is Heightened in Pemphigus Vulgaris and Is Driven by Human Leukocyte Antigen Status and the Absence of Desmoglein Reactivity. Front. Immunol. 9:625. doi: 10.3389/fimmu.2018.00625 anti-Thyroid Peroxidase reactivity is heightened in Pemphigus Vulgaris and is Driven by human leukocyte a...
discussion we have to stress that the importance of this case report is its presentation in an elderly patient, as the frequent age of presentation in the iranian patients is the middle age. on the other hand, pv occurs rarely, thus, the reporting of any rare case with some exceptions is important. case presentation we reported a case of pemphigus vulgaris in a 79-year-old patient with the exte...
Nail involvement in pemphigus vulgaris is rare. We describe 5 patients with pemphigus vulgaris presenting nail involvement. In this disease, nail manifestations present, by order of frequency, as chronic paronychia, onychomadesis, onycholysis, Beau's lines and trachyonychia. All our 5 cases presented with paronychia, and 1 of them also had Beau's lines. Treatment with prednisone and/or cyclopho...
Oral mucous membranes may be affected by a variety of blistering mucocutaneous diseases. In this paper, we review the clinical manifestations, typical microscopic and immunofluorescence features, pathogenesis, biological behaviour and treatment of pemphigus vulgaris. Although pemphigus vulgaris is not a common disease of the oral cavity, its potential to cause severe or life-threatening disease...
Background: A clinicopathological study of 75 cases of pemphigus was carried out at Saurashtra region of Gujarat State, India. This study was done to subtype this disease with evaluation of clinical and histopathological presentation. Methods: The study was carried out in a two-year period at skin department of Guru Gobind Singh Hospital, Jamnagar. Seventy five patients of pemphigus were examin...
The mainstay of treatment of pemphigus vulgaris is systemic corticosteroids. Intravenous immunoglobulins have been reported as an adjuvant corticosteroid-sparing regimen in recalcitrant pemphigus vulgaris. The purpose of the study was to monitor disease activity, serum levels of autoantibodies and doses of oral corticosteroids in 4 patients with recalcitrant pemphigus vulgaris adjuvantly treate...
We describe the case of a 67-year-old woman affected by pemphigus vulgaris with a dry whitish scaly lesion in the upper lip. Clinically, this lesion resembled an actinic keratosis. Although histological examination revealed a focal acantholysis, the finding of a moderate-to-severe dysplastic epithelium was consistent with the diagnosis of acantholytic actinic keratosis with moderate/severe dysp...
Pemphigus vulgaris is an autoimmune bullous disease whose therapy is based on systemic corticosteroids, with or without immunosuppressants. Rituximab is a chimeric monoclonal antibody of the IgG class, directed at a specific CD20 B cell surface antigen, used in pemphigus vulgaris empirically since 2002, with success in 90% of the cases and long periods of remission. Male patient, 33 years old, ...
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