نتایج جستجو برای: pepsinogens
تعداد نتایج: 310 فیلتر نتایج به سال:
Gastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrop...
The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged > or =40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-200...
T HAS BEEN NOTED by several authors that in uropepsin determination a major proportion of the total activity is due to conversion of pepsinogen to pepsin, whereas a small proportion of the activity obtained is due to some system other than pepsin. As a result of this, in the quantitative determination of uropepsin some specimens give results which are erroneously high. Several methods for deter...
Chicken pepsinogen was incubated at pH2.5 with pepstatin. The zymogen activated itself by a sequential mechanism and an intact peptide derived from residues 1-26 in the protein was released in the first step. This peptide was found to inhibit the milk-clotting activities of pig and chicken pepsins and calf chymosin but to different extents.
Phenylbutazone in moderate dosage has been administered to 15 patients with a variety of musculo-skeletal disorders. A rise in plasma pepsinogen activity occurred in 13, generally reaching a peak in the first week of treatment; subsequently there was a fall in spite of maintaining a constant dosage. In four of six patients an anticholinergic drug failed to prevent a rise in plasma pepsinogen ac...
Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of 21 given ranitidine (62%); two patients on cimetidine and two on ranitidine d...
The conversion of pepsinogen to pepsin has been followed by means of the fluorescent probe, Z-p-toluidinonaphthalene6-sulfonate (TNS). It was found that the change in fluorescence accurately reflects the formation of active pepsin. The data on the binding of TNS to pepsinogen and pepsin suggest that the environment surrounding the fluorophore is altered during the conversion. One of the peptide...
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