Peptic ulcer is a Common diseuse with potentially serious complications. Perforation of the one such complication that can be fatal if left untreated. We present rare case kissing peptic ulcers in 42-year-old patient who presented hematemesis and melena was admitted to intensive care unit hemorrhagic shock post trauma. Despite failed endoscopic hemostasis measures, successfully treated surgical...

Acute ulcers of the gastric mucosa are found in a large percentage of dogs and cats dying after adrenalectomy. These ulcers seem to develop during the moribund period. They are apparently peptic ulcers forming at the site of local hemorrhages in the gastric mucosa. They are true acute ulcers, usually penetrating to the muscularis mucosa with a total loss of epithelium. They develop in the absen...

Peptic ulcer disease (PUD) is predicted to affect between 0.1 and 0.3 percent of the population each year. PUD develops at a rate roughly 1% per year in Helicobacter pylori (H. pylori) infected persons, which 6 10 times higher than uninfected people. The prevalence increases with age both duodenal stomach ulcers. Two factors contribute peptic disease: H. infection use nonsteroidal anti-inflamma...

Acid peptic diseases are common gastrointestinal disorders, which include gastroesophageal reflux disease, peptic ulcers, non-ulcer dyspepsia and stressrelated gastric mucosal injury. Drugs commonly used in the management of these disorders include antacids, H2 blockers, proton pump inhibitors and mucosal protective agents. In this chapter, pharmacology of these drugs will be discussed, followe...

The functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the ABCB1 gene encoding the xenobiotic transporter P-glycoprotein (P-gp) may influence susceptibility to several diseases, as well as the clinical outcome of treatment with P-gp substrates. Exposure to environmental chemicals is thought to be involved in peptic ulcer pathogenesis and then later in stomach cancer developmen...