Assisting drug repositioning processes can lead to a considerable reduction in cost and time in any drug development process. Recent in silico approaches have addressed the network-based nature of biological information to assess the possible new indications for a query drug. Here we present a new methodology based on network prioritization, that can aid researchers in the drug repositioning pr...

In transportation via containers, unbalanced movement of loaded containers forces shipping companies to reposition empty containers. This study addresses the problem of empty container repositioning (ECR) in the distribution network of a European logistics company, where some restrictions impose decision making in an uncertain environment. The problem involves dispatching empty contain...

The ability of firms to reposition their products can determine the effects of demand shocks, mergers and policy interventions in differentiated product markets. This paper estimates a dynamic oligopoly model to measure repositioning costs in the commercial radio industry. Based on a set of markets where industry revenues were around $88 billion, I find that stations may have spent as much as $...

We solve the liner shipping fleet repositioning problem (LSFRP), a key problem in the liner shipping industry, using a hybrid reactive tabu search and simulated annealing algorithm in combination with novel local search neighborhoods. Liner carriers reposition vessels between services in order to add, remove or modify services in their network. Repositioning vessels costs between hundreds of th...

Development of new medications is a very lengthy and costly process. Finding novel indications for existing drugs, or drug repositioning, can serve as a useful strategy to shorten the development cycle. In this study, we present an approach to drug discovery or repositioning by predicting indication for a particular disease based on expression profiles of drugs, with a focus on applications in ...

[Purpose] This study was conducted in order to investigate the effect of repetitive passive movement and repetitive active movement on proprioception in forearm supination. [Subjects] This study had a cross-sectional design. Twenty-three right-handed healthy subjects were recruited. All subjects randomly received both repetitive passive movement and repetitive active movement (repetitive passiv...

Increase in global population and growing disease burden due to the emergence of infectious diseases (Zika virus), multidrug-resistant pathogens, drug-resistant cancers (cisplatin-resistant ovarian cancer) and chronic diseases (arterial hypertension) necessitate effective therapies to improve health outcomes. However, the rapid increase in drug development cost demands innovative and sustainabl...

[Purpose] This study evaluated the effect of smartphone use on lumbar spine repositioning error and lumbar curvature while walking on a treadmill. [Subjects] A total of 20 healthy individuals (18 males and 2 females) volunteered for this study. [Methods] The subjects walked for 20 min on a treadmill while using a smartphone. To determine the effect of smartphone use, lumbar repositioning error ...

Awake proning or repositioning has been endorsed in several national and international guidelines for the management of patient suffering from COVID-19 with moderate to severe respiratory distress where appear respond well treatment position changing. Repositioning is done improve ventilation also secretion clearance. For this nurses must be aware about technique used awake provide education am...

Uterine incarceration is a rare condition that can develop during pregnancy when an enlarging retroverted uterus becomes entrapped within the maternal pelvis. Diagnosis be challenging as it often presents with vague symptoms, but identification and treatment are crucial for both developing long-term morbidity. Repositioning of necessary development normal occur spontaneously, oftentimes manual ...