Electrical stimulation of the dorsal regions of the periaqueductal gray (PAG) leads to defensive reactions characterized as freezing and escape responses. Until recently it was thought that this freezing behavior could be due to the recruitment of neural circuits in the ventrolateral periaqueductal gray (vlPAG), while escape would be mediated by other pathways. Nowadays, this view has been chan...

Significance Predatory hunting involves measured risk taking by the predator to anticipate dangerous defensive behavior from prey. This a mechanism where motivation hunt can overcome behaviors toward prey unlock attack. Here, we found that activation of subset GABAergic neurons in lateral hypothalamus (LHA) promotes but not feeding behavior. Stimulation projections these periaqueductal gray (PA...

An astonishing level of detail is known about the circuits that mediate the acquisition of Pavlovian conditional fear. Considerable attention has been focused on the amygdala, and to be sure, amygdala activity is normally essential for fear conditioning. However, the complete circuit involves frontal cortex, hippocampus, periaqueductal gray (PAG) Developmental Psychobiology. DOI 10.1002/dev 650...