1 attachment, which is lost during disease. This type of regeneration is described by the term 'New attachment'. New attachment is the embedding of new periodontal ligament fibres on to new cementum previously denuded by the periodontal disease. Factors interfering with new attachment are plaque, calculus, infected cementum and alterations in mineral density and composition of root. These obsta...

Radicular cyst is the most common odontogenic cystic lesion of inflammatory origin. It is also known as periapical cyst, apical periodontal cyst, root end cyst, or dental cyst. It arises from epithelial residues in the periodontal ligament as a result of inflammation. The inflammation usually follows the death of dental pulp. This paper presents a case report of a patient with radicular cyst as...

The repair of bone defects that result from periodontal diseases remains a clinical challenge for periodontal therapy. β-tricalcium phosphate (β-TCP) ceramics are biodegradable inorganic bone substitutes with inorganic components that are similar to those of bone. Demineralized bone matrix (DBM) is an acid-extracted organic matrix derived from bone sources that consists of the collagen and matr...

Ligament is prone to injury and degeneration and has poor healing potential and, with currently ineffective treatment strategies, stem cell therapies may provide an exciting new treatment option. Ligament-derived stem cell (LDSC) populations have been isolated from a number of different ligament types with the majority of studies focussing on periodontal ligament. To date, only a few studies ha...

PURPOSE The aim of this study was to identify a role for endodontic intervention in enhancing the regenerative potential of the periodontal ligament when combined with periodontal treatment in seriously involved teeth with a secondary endodontic component. METHODS Patients who exhibited radiolucency extending to the periapical region, abnormal electric pulp testing values, and deep probing de...

noninvasive tool that can aid in the evaluation of the entire spectrum of internal derangements of the knee. Although the cost varies considerably across the country, the average cost of knee MRI is on the order of several hundred to more than a thousand dollars. The noninvasiveness of MRI combined with its relatively low cost have led to its acceptance by the orthopaedic community, and MRI of ...

This work reports the covalent immobilization of tetracycline and rolitetracycline over anionic collagen membranes and the drug release studies as an effort to develop a two stage drug release based on diffusion (fast release) and on the rate of membrane biodegradation (slow release). Independent from casting conditions antibiotics incorporated by dispersion were released in the range from 80 t...

P53 is considered one of the most important defense proteins against cancer.Although the p53 mutation is associated with many cancers, its mutation is never found in Kaposi’s sarcoma (KS), raising a possibility that functional p53 may play a role in KS development. To assess the role of p53 in Kaposi’s sarcoma tumor, shRNA-mediated gene silencing was used to knockdown p53 expression. We examine...

Craniosynostosis occurs in one of 2500 live human births and may manifest as craniofacial disfiguration, seizure, and blindness. Craniotomy is performed to reshape skull bones and resect synostosed cranial sutures. We demonstrate for the first time that autologous mesenchymal stem cells (MSCs) and controlled-released TGFbeta3 reduced surgical trauma to localized osteotomy and minimized osteogen...