..................................................................................................................8 REVIEW OF THE LITERATURE ...............................................................................9 Introduction....................................................................................................................9 Glial cell line-derived neurotrophic factor f...

BACKGROUND Involvement of the peripheral nervous system in the pathogenesis of prion diseases is becoming increasingly evident. However, pathologic protease-resistant prion protein deposition in the peripheral nerves of patients with Creutzfeldt-Jakob disease has never been demonstrated, to our knowledge. OBJECTIVE To determine whether mutated prion protein accumulation could be shown in the ...

Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system. This chapter will revise the current k...

Recklinghousen in 1891 were not examples of osteitis fibrosa generalisata and hence of hyperaparathyroidism, but were suffering from "polyostotic fibrous dysplasia." The book concludes with an account of Paget's disease, vith an ingenious, if not very satisfactory, attempt to explain its pathological physiology. It, however, has some useful points in treatment, one or two glasses of milk daily ...