T elomere association with nuclear pores is critical not only for transcriptional silencing but also for effi cient repair of double-stranded breaks in the subtelomeric region of budding yeast chromosomes, according to Therizols et al. (page 189). As in many organisms, yeast telomeres localize to the nuclear periphery. To determine whether nuclear pore proteins are involved in telomere tetherin...

Doris Hausen University of Munich

CASE REPORT A 39-year-old woman presented in November 1994 to the Accident and Emergency Department of the Birmingham and Midland Eye Hospital with a recent onset of a shadow and floaters in the temporal field of her vision of her left eye. She had previously attended in October 1993 with an unusual appearance of the temporal periphery of the right retina. This lesion was thought to be a retino...

Studies of the neural control of locomotion have tended to focus on the modulation of motoneuron firing by premotor neurons; new work indicates that the regulation of synaptic transmission at the neuromuscular junction can also be important, revealing an inverse relationship between input resistance and synaptic output in motoneurons.

Preface I come from Poland. Several months ago I came to Eindhoven to do my studies. I followed master programme Human-Technology Interaction at the Eindhoven University of Technology. In the last phase of this study I joined Philips Research, the group of Visual Experiences, where I completed my graduation project. This report is a result of this project. I would like to thank all the people w...

In this paper, I begin by suggesting digital photographic images should be considered as being neither a purely visual experience nor a purely perceptual one. Instead, I argue these may be somewhat limiting terms which confine our engagement with images to traditional linguistic interpretations. At a time when digital images are more amenable and liable to forms of recombination, fragmentation ...

Recently, the Hungarian Geographical Bulletin – that had been a forum for introducing empirically focused papers covering various social and physical geographical issues for decades – became engaged increasingly in academic discourses on socio-spatial inequalities, embracing various approaches and problems with diff erent scalar foci. The theoretical and methodological diversity that ranged fro...

TCRs alive on the periphery eeping T cell receptors (TCRs) away from the center of the immunological synapse boosts stimulatory stignals, based on work from The immunological synapse—the cell–cell junction between a T cell and antigen-presenting cell (APC)—looks like a bull's eye, with a central cluster of TCRs and their bound antigen–MHC ligands surrounded by a ring of adhesion molecules and t...

GAL genes and other activated yeast genes remain tethered to the nuclear periphery even after transcriptional shutoff. To identify factors that affect this tethering, we designed a plasmid-based visual screen. Although many factors affected GAL tethering during transcription, fewer specifically affected posttranscriptional tethering. Tw o of these, Rrp6p and Lrp1p, are nuclear exosome component...