BACKGROUND AND PURPOSE Perivascular (PV) spaces are known to distend and cause edema along the optic tract (OT) in pituitary-region tumors. Interstitial fluid may be retained in PV spaces when tumors block their drainage outlets to subarachnoid spaces. However, these spaces and their outlets have not been anatomically elucidated. Our purpose was to evaluate how often large PV spaces are present...

The infiltration of immune cells in the central nervous system is a common hallmark in different neuroinflammatory conditions. Accumulating evidence indicates that resident glial cells can establish a cross-talk with infiltrated immune cells, including T-cells, regulating their recruitment, activation and function within the CNS. Although the healthy CNS has been thought to be devoid of profess...

1. When living or dead tubercle bacilli and their products are placed in direct contact with the leptomeninges of hypersensitive (tuberculous) animals, there is a definite clinical and pathological response. 2. The clinical response is characterized by an onset of weakness, twitchings, convulsions and death of the animal within 6 to 12 hours. 3. Histologically the central nervous system shows a...

PURPOSE One of the central features of brain aging is the accumulation of multiple age-related structural changes, which occur heterogeneously in individuals and can have immediate or potential clinical consequences. Each of these deficits can coexist and interact, producing both independent and additive impacts on brain health. Many of the changes can be visualized using MRI. To collectively a...

The blood-brain barrier (BBB) isolates the CNS from the rest of the organism. The anatomic foundation of this structure is a syncytium of cerebrovascular endothelial cells sealed together by tight junctions. The endothelial basal lamina, located at the abluminal side of endothelium, borders the perivascular (Virchow-Robin) space. The perivascular space is continuous with the subarachnoid compar...

Objectives To compare the ablation margins and safety of microwave (MWA) perivascular versus non-perivascular liver metastases from colorectal cancer (CRC) to determine risk factors for local tumor progression (LTP) after MWA.Methods Between June 2017 2019, 84 were treated: 39 (<5 mm a vessel >3 mm), 46 non-perivascular. Perivascular treated with either conventional or optimized protocols (maxi...