PURPOSE The goal of this study was to determine whether a synthetic peptide, NC-1059, can modulate the corneal epithelium to increase the permeation of therapeutic agents across this barrier. METHODS An in vitro system employing transformed human corneal epithelial (THCE) cells was optimized for this study. Culture conditions were identified to promote formation of a confluent monolayer that ...

Perovskites are known as mixed electric conductors because they show both electronic (via electron holes) and ionic (via oxygen vacancies) conductivity. Since the electron conductivity is orders of magnitude higher than the ionic one, oxygen vacancy bulk diffusion is regarded as the rate limiting step in oxygen permeation through perovskites. However, for thin perovskite layer the rate of this ...

The objective of this work is to evaluate the effect of polyamidoamine (PAMAM) dendrimers on electroosmotic flow (EOF) through skin. The effect of size and concentration of dendrimer was studied, using generation 1, 4 and 7 dendrimer (G1, G4 and G7, respectively). As a marker molecule for the direction and magnitude of EOF, a neutral molecule, acetoaminophen (AAP) was used. The visualization of...

The possibility of applying liposomes as a topical drug delivery system is still a matter of intensive research. The purpose of this study was to determine the suitability of liposomes as carriers of naproxen and to prove their impact on the effectiveness of transdermal permeation of an active substance. The study was conducted with the use of Franz Diffusion Cell System by comparing the effica...

For the first time, a tubular asymmetric ceramic-carbonate dual phase membrane was prepared by a centrifugal casting technique and used for high temperature CO2 separation. This membrane shows high CO2 permeation flux and permeance.

Dermal permeation through human epidermis and uptake into isolated human stratum corneum (SC) that was and was not delipidized were measured for 2 model compounds, 4-cyanophenol (CP) and methyl paraben (MP), from saturated aqueous solutions containing 1 or both compounds. Because the solutions were in equilibrium with the pure CP and MP, the thermodynamic activity of the compounds was constant....

In this paper, results of the oily wastewater treatment by ceramic membranes in microfiltration process are simulated using neural network and hermia model. The process simulation by neural networks is written using MATLAB software program. The network input consisted of oil concentration (Coil), cross-flow velocity (CFV), temperature (T), trans-membrane pressure (TMP), and filtration time (t) ...

A consistent description of the hydrogen permeation through metal membrane based on hydrogen chemical potential proposed has been explained in detail. The hydrogen flux is proportional to the PCT factor, fPCT, consistently, which reflects the shape of the pressure-composition-isotherm (PCT curve) of the material. In addition, in view of the PCT factor, fPCT, and the ductile-to-brittle transitio...