A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent p...

Extremely small iron oxide nanoparticles (ESIONPs), which have a switchable contrast signal and favorable biocompatibility, are gaining considerable attention as smart magnetic resonance imaging (MRI) agents (CAs). Adaptive MRI CAs could improve the accuracy of tumor diagnosis because they realize rapid conversion under an endogenous stimulus. Herein, based on hydrophilic to hydrophobic transit...

The use of polymer-membrane pH electrodes as internal sensing elements for the fabrication of inexpensive ammonia and carbon dioxide gas sensing systems is reported. The pH-responsive polymer membranes are prepared by incorporating tridodecylamine as the neutral carrier in plasticized poly(viny1 chloride) membranes. Both static and continuous-flow gas-sensing arrangements are described. For min...

Biopolymers composed of a pH-responsive, hydrophilic poly(methacrylic acid-grafted-ethylene glycol) network polymerized in the presence of poly(methyl methacrylate) nanoparticles were designed for the oral delivery of chemotherapeutics for the treatment of colon cancer. An inulin-doxorubicin conjugate, designed to target the colon and improve doxorubicin efficacy, was loaded into these polymer ...

Omeprazole, a proton-pump inhibitor used in peptic ulcers, gastro-esophageal-reflux disorder, Zollinger-Ellison syndrome and in H. pylori infections. The omeprazole is unstable at acidic pH, undergoes degradation in stomach. To prevent the degradation in stomach, dosage forms are supplied as enteric-coated tablets or granules encapsulated in gelatin capsules. The efficiency of such dosage forms...

Functional materials engineered to degrade upon triggering are in high demand due their potentially lower impact on the environment as well use sensing and medical applications. Here, stimuli-responsive polymers prepared by decorating a self-immolative poly(dithiothreitol) backbone with pendant catechol units. The highly functional polymer is fashioned into gels, formed through pH-dependent cat...

Temperature- and pH-sensitive amphiphilic polymer poly(N-isopropylacrylamide-co-acrylic acid-co-cholesteryl acrylate) (P(NIPAAm-co-AA-co-CHA)) has been synthesized and employed to encapsulate paclitaxel, a highly hydrophobic anticancer drug, in core-shell nanoparticles fabricated by a membrane dialysis method. The nanoparticles are spherical in shape, and their size can be made below 200 nm by ...

Stimuli−responsive polymers respond with large property changes to small physical or chemical stimuli. These functional polymers are known as “smart”, “intelligent”, “stimuli−responsive”, or “environmentally sensitive” polymers. They can take many forms: they may be dissolved in aqueous solution, adsorbed or grafted on aqueous−solid interfaces, or cross−linked in the form of hydrogels. Many dif...

Introduction In recent years, there has been a great interest in the fabrication of stimuli responsive polymer microspheres for technological application and fundamental studies. These stimuli responsive smart and intelligent polymeric materials can respond in shape or volume changes to small external stimuli such as temperature, pH and ionic strength etc [1, 2]. Among these stimuli responsive ...