BACKGROUND Features of the tumor microenvironment influence the efficacy of cancer nanotherapeutics. The ability to directly radiolabel nanotherapeutics offers a valuable translational tool to obtain biodistribution and tumor deposition data, testing the hypothesis that the extent of delivery predicts therapeutic outcome. In support of a first in-human clinical trial with (64)Cu-labeled HER2-ta...

BACKGROUND Patient-specific absorbed dose calculations for molecular radiotherapy require accurate activity quantification. This is commonly derived from Single-Photon Emission Computed Tomography (SPECT) imaging using a calibration factor relating detected counts to known activity in a phantom insert. METHODS A series of phantom inserts, based on the mathematical models underlying many clini...

Background: Gel polymers are considered as new dosimeters for determining radiotherapy dose distribution in three dimensions.Objective: The ability of a new formulation of MAGIC-f polymer gel was assessed by experimental measurement and Monte Carlo (MC) method for studying the effect of gold nanoparticles (GNPs) in prostate dose distributions under the internal Ir-192 and external 18MV radiothe...

OBJECTIVE The purpose of this study is to estimate a patient's organ dose (effective dose) during performance of dual X-ray absorptiometry by using the correlations derived from the surface dose and the depth doses in an anthropomorphic phantom. MATERIALS AND METHODS An anthropomorphic phantom was designed and TLDs (Thermoluminescent Dosimeters) were placed at the surface and these were also ...

We validated 3D radiochromic film dosimetry for volumetric modulated arc therapy (VMAT) using a newly developed spiral water phantom. The phantom consists of a main body and an insert box, each of which has an acrylic wall thickness of 3 mm and is filled with water. The insert box includes a spiral film box used for dose-distribution measurement, and a film holder for positioning a radiochromic...

In this study, we have fabricated a scintillating fiberoptic dosimeter (SFOD) for a Co-60 radiotherapy dosimetry. The γrays generated from a Co-60 machine are measured using a SFOD and percent depth dose (PDD) curves are obtained according to the different depths of water phantom. Also, Cerenkov lights generated by the interactions of primary or secondary electrons and a plastic optical fiber a...

High-molecular gel containing capsulate thermo-chromic liquid crystal is made to visualize three-dimensional distribution of electromagnetic power absorption. A preliminary experiment is performed at frequency of 1.5GHz. As a result of the experiment, the three-dimensional distribution of electromagnetic power absorption is clearly visualized. The result shows that the gel can be used as a phan...

The aim of this report is to present a new two-piece thyroid-neck phantom produced by the concurrent use of epoxy resin and poly(methyl methacrylate) (PMMA: plexiglass) soft tissue equivalent materials. Accordingly, mass attenuation coefficients of the epoxy resin and the plexiglass compounds were obtained from simulation (NIST XCOM 3.1) and measurements (practical dosimetry) and compared to th...