Diosmin and hesperidin are natural flavonoid glycosides found in various plant materials, mainly in citrus fruits in different concentrations. Diosmin for pharmaceutical use is obtained mainly semi-synthetically from hesperidin. Hesperidin often accompanies diosmin as a natural impurity in different pharmaceutical formulations; therefore, a simple, fast and precise method for the simultaneous a...

Four spectrophotometric methods are described and applied to resolve ternary mixtures of the corticosteroid Dexamethasone (DEX), the antibiotic Polymyxin B (PLX) and its encouraging Trimethoprim (TMP). The simultaneous determination of these three compounds was firstly accomplished by a derivative method using the “ratio spectrum-zero crossing derivative” (satisfactory results in synthetic mixt...

Diosmin and hesperidin are natural flavonoid glycosides found in various plant materials, mainly in citrus fruits in different concentrations. Diosmin for pharmaceutical use is obtained mainly semi-synthetically from hesperidin. Hesperidin often accompanies diosmin as a natural impurity in different pharmaceutical formulations; therefore, a simple, fast and precise method for the simultaneous a...

Compound-specific isotope analysis (CISA) of nonvolatile analytes has been enabled by the introduction of the first commercial interface to hyphenate liquid chromatography with an isotope ratio mass spectrometer (LC-IRMS) in 2004, yet carbon isotope analysis of unpolar and moderately polar compounds is still a challenging task since only water as the eluent and no organic modifiers can be used ...

The pharmaceutical industry embraced the concept of control banding many years ago. Control banding is a process of assigning a compound to a hazard category that corresponds to a range of airborne concentrations – and the engineering controls, administrative controls, and personal protective equipment – needed to ensure safe handling. While the terminology used was different, the high potency ...

A simple method is presented for the analysis of 13 pharmaceutical and pharmaceutical metabolite compounds in sewage effluents and surface waters. The pharmaceutical compounds were extracted using a genetic solid-phase extraction (SPE) procedure using Phenomenex Strata X as a stationary phase. Extracts were quantitatively analysed by four separate reversed-phase high-performance liquid chromato...

in recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. high-performance liquid chromatography is a very useful method for the direct separation of enantiomers. however, about 30−40 years ago, commercially available chiral stationary phases wer...

IN T RO DU C T IO N Preparative chromatography is the technique of choice for isolation and purification of different types of compounds, including pharmaceutical drug candidates, target compounds from synthetic mixtures, and bioactive compounds from natural products. As a result, there has been continuous research interest in improving the fundamental knowledge and instrumentation of preparati...

A practical protocol to obtain accurate heat capacity values of pharmaceutical compounds using modulated-temperature differential scanning calorimetry was established. Three pharmaceutical compounds, acetaminophen, indomethacin, and tri-O-methyl-β-cyclodextrin were used as model compounds. Powder samples did not produce reproducible results, presumably due to inclusion of gas in gap of powders ...

HIGHLIGHTS Chemical characterization of PA extracts has high content phenolic compounds. from G. angustifolia may be used in the pharmaceutical industry and agriculture. A total 66 compounds with approximate match percentage ≥ 89% were identified. The showed a antioxidant properties.