Successful treatment of infectious diseases requires choice of the most suitable antimicrobial agent, comprising consideration of drug pharmacokinetics (PK), including penetration into infection site, pathogen susceptibility, optimal route of drug administration, drug dose, frequency of administration, duration of therapy, and drug toxicity. Antimicrobial pharmacokinetic/pharmacodynamic (PK/PD)...

The ability to identify agents with the optimal combination of potency, pharmacokinetics and pharmacodynamics should help to maximize bacteriological cure and thus minimize the potential for selection and spread of resistance. Gemifloxacin demonstrated excellent correlation between efficacy and the AUC0-24h/MIC ratio whereas there was little correlation with time above MIC. Thus, gemifloxacin i...

FocalinTM XR (dexmethylphenidate hydrochloride) extended-release capsules is an extended-release formulation of dexmethylphenidate with a bi-modal release profile. FocalinXR uses the proprietary SODASTM (Spheroidal Oral Drug Absorption System) technology. Each bead-filled Focalin XR capsule contains half the dose as immediate-release beads and half as enteric-coated, delayed-release beads, thus...

ABBREVIATIONS IN THIS CHAPTER AKI Acute kidney injury Clh Hepatic clearance Clint Intrinsic clearance Cmax Maximum concentration CYP450 Cytochrome P450 Eh Hepatic extraction efficiency or ratio Fu Fraction unbound GFR Glomerular filtration rate KDIGO Kidney Disease: Improving Global Outcomes LNPEP Leucyl/cystinyl aminopeptidase PCI Percutaneous coronary intervention PD Pharmacodynamics PGx Phar...