Abstract Objective This study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression survival outcome in advanced pharyngeal cancer without human papillomavirus infection. Method Twenty-five oropharyngeal 55 hypopharyngeal patients infection were enrolled. All had stage III–IV lesions underwent concurrent chemoradiotherapy or surgery....

PURPOSE Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic alpha (PIK3CA) gene in several human solid tumors. Although gene amplifications of PIK3CA have been reported in head and neck squamous cell carcinoma (HNSCC), small mutation of the gene has not been evaluated in HNSCC previously. In this study, we examined the mutation frequency...

BQ chewing may produce significant amounts of reactive oxygen species (ROS), resulting in oral mucosa damage, and ROS may be metabolized by CYP26 families. Because the CYP26 polymorphisms associated with malignant oral disorders are not well known, we conducted an association study on the associations between the single nucleotide polymorphisms (SNP) of CYP26 families and the risks of malignant...

OBJECTIVE By performing sentinel lymph node (SLN) biopsy, its detecting and predictive value to the cervical metastasis in the head and neck cancer patients was studied. METHODS Intraoperative SLN biopsy was done in 51 untreated head and neck cancer patients who all had no metastasis before operation. The lesions were: laryngeal cancer 23, pharyngeal cancer 6, thyroid cancer 20 and cancer of ...

introduction: pharyngocutaneous fistula (pcf) is the most common complication after total laryngectomy. its incidence is extremely variable, with values ranging from 3% and 65%. the management of this problem considerably increases the length and the cost of hospitalization.  the aim of this study is to analyze the incidence, predisposing factors, and outcome of pcf in patients undergoing total...

Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowel (1394 colon, 886 rectum, 4765 controls), breast (2900 cases, 3122 controls) ...

BACKGROUND Large inequalities of mortality by most cancers in general, by mouth and pharynx cancer in particular, have been associated to behaviour and geopolitical factors. The assessment of socioeconomic covariates of cancer mortality may be relevant to a full comprehension of distal determinants of the disease, and to appraise opportune interventions. The objective of this study was to compa...