BACKGROUND The periodic health evaluation (PHE) has been a fundamental part of medical practice for decades despite a lack of consensus on its value. PURPOSE To synthesize the evidence on benefits and harms of the PHE. DATA SOURCES Electronic searches of such databases as MEDLINE and the Cochrane Library, review of reference lists, and hand- searching of journals through September 2006. S...

Fluorescence studies on the interaction, with porcine pepsin, of oligopeptides bearing a mansyl (Mns, 6-(N-methylanilino)-2-naphthalenesulfonyl) or dansyl (Dns, 5-dimethylaminonaphthalene-1-sulfonyl) group at the NH2 or COOH terminus have provided further evidence showing that the probe group is drawn into the extended active site largely as a consequence of the specific binding of the peptide ...

The mode(s), geometry and strength of interaction of the three aromatic amino acids, namely Phe, Tyr and Trp, with the benzyl side chain of Phe, at the non-hydrogen bonding position of designed model octapeptide β-hairpins, nucleated by the central (D)Pro-Gly turn, have been examined. In the absence of solvent-driven hydrophobic forces, the extent of contribution of such interactions indicates ...

Hyperphenylalaninemia (HPA) refers to all clinical conditions characterized by increased amounts of phenylalanine (PHE) in blood and other tissues. According to their blood PHE concentrations under a free diet, hyperphenylalaninemic patients are commonly classified into phenotypic subtypes: classical phenylketonuria (PKU) (PHE > 1200 µM/L), mild PKU (PHE 600-1200 µM/L) and persistent HPA (PHE 1...

Kirromycin, a new inhibitor of protein synthesis, is shown to interfere with the peptide transfer reaction by acting on elongation factor Tu (EF-Tu). All the reactions associated with this elongation factor are affected. Formation of the EF-Tu.GTP complex is strongly stimulated. Peptide bond formation is prevented only when Phe-tRNA(Phe) is bound enzymatically to ribosomes, presumably because G...

The use of the phase change material (PCM) as a storage medium represents an important advance to store energy for absorption cooling systems when solar is not available; however, temperature tank key parameter adequate operation system. This paper presents parametric analysis flat and commercial plate heat exchangers with MgCl2·6H2O PCM at conditions. exchanger (PHE) chevron type angle 45° are...

α-Tubulin C-terminus undergoes post-translational, cyclic tyrosination/detyrosination, and L-Phenylalanine (Phe) can be incorporated in place of tyrosine. Using cultured mouse brain-derived cells and an antibody specific to Phe-tubulin, we showed that: (i) Phe incorporation into tubulin is reversible; (ii) such incorporation is not due to de novo synthesis; (iii) the proportion of modified tubu...

Breast Cancer Therapy In article number 2201971, Ruibing Wang and co-workers develop supramolecular peptide (based upon the host–guest interaction between cucurbit[7]uril Phe-Phe-Val-Leu-Lys) capped Au nanocages, to allow self-aggregation into micron-sized clusters inside spermine-overexpressed tumor cells, leading specific accumulation retention of nanocages in breast for synergistic photother...