In order to characterize the promoting activity of the peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,463), male F344 rats which received a single 150-mg/kg dose of diethylnitrosamine (DEN) were fed 0.1% WY-14,643 or 0.05% phenobarbital in the diet for 11, 22, or 54 wk. WY-14,643 promoted the development of ATPase-deficient foci but not GGTase-positive o...

Chem. Abstr. Serv. Reg. No.: 57-30-7 Deleted CAS Reg. Nos: 125-36-0; 8050-96-2 Chem. Abstr. Name: 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, monosodium salt IUPAC Systematic Name: 5-Ethyl-5-phenylbarbituric acid, sodium salt Synonyms: 5-Ethyl-5-phenylbarbituric acid sodium; phenobarbital sodium; phenobarbitone sodium; sodium ethylphenylbarbiturate; sodium 5-ethyl-5-phenylbarbiturate; so...

PO: Within 20-60 minutes. IV:PO conversion is 1:1.. Maintenance phenobarbital doses of 5 mg/kg/day may occasionally result in accumulation of serum . J Clin Pharmacol. 1978 Feb-Mar;18(2-3):100-5. Bioavailability of oral and intramuscular phenobarbital. Viswanathan CT, Booker HE, Welling PG. Jul 25, 2017. BRIVIACT can be initiated with either intravenous or oral administration. tablets to carbam...

Purpose: Screening scale studies were performed with eight cultures for their ability to metabolize phenobarbital, an antiepileptic, sedative, hypnotic and substrate for CYP 2C9 and 2C19. Methods: The transformation of phenobarbital was confirmed and characterized by fermentation techniques, high performance liquid chromatography (HPLC), mass spectrometry (MS) and metabolism inhibition studies....

Gluconeogenesis was studied in hepatocytes isolated from phenobarbital-pretreated rats fasted for 24 h. In closed vial incubations, glucose production from lactate (20 mmol/l) and pyruvate (2 mmol/l), alanine (20 mmol/l) or glutamine (20 mmol/l) was suppressed by about 30-45%, although glycerol metabolism was not affected. In hepatocytes perifused with lactate and pyruvate (ratio 10:1), glucose...

Gap junction-mediated intercellular communication in untreated and phenobarbital-treated C57BL/6 X C3H F1 mouse hepatocytes was evaluated by microinjection of fluorescent Lucifer Yellow CH dye. Intercellular communication (dye coupling) was detected in untreated hepatocytes after 0.5 h in culture, reached a maximum level in 24- and 48-h-old cultures (85.2%), and then decreased over the next 72 ...

Drug treatment of neonates and infants and its long-term consequences on drug responses have emerged in recent years as amajor challenge for health care professionals. In the current study, we use phenobarbital as a model drug and mouse as an in vivo model to demonstrate that the dose of phenobarbital and age of treatment are two key factors for the persistent induction of gene expression and c...

OBJECTIVE To evaluate the effect of high dose phenobarbital on lipid peroxidation and antioxidant enzymes in perinatal asphyxia. DESIGN Open label, Randomized controlled trial. SETTING Neonatal intensive care unit of a tertiary care teaching hospital. PARTICIPANTS 72 full term inborn neonates with severe birth asphyxia. METHODS Neonates were randomized to Study (phenobarbital) group and...