Anion sensing is a dynamic research field due to the biological and environmental importance of some organic or inorganic anions. Hydrazones show promising properties in design anion chemosensors presence proton donor acceptor sites their structure. In this work, two novel dinitrophenyl hydrazones, functionalized with quinoline moiety, were synthesized characterized by spectroscopic spectrometr...

A diastereoselective synthesis of cyclic hydrazines was achieved from a carbocyclisation of allene-hydrazones by the Pd-catalyzed distannylation of an allene moiety, followed by the transmetallation of allylic stannane intermediates with TiCl4.

In continuation of our endeavor towards the development of potent and effective antimicrobial agents, three series of halophenyl bis-hydrazones (14a-n, 16a-d, 17a and 17b) were synthesized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the identification of five molecules 14c, 14g, 16b, 17a and 17b (MIC range from 0.12 to 7.81 ...

Some new biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides have been synthesized and evaluated for anti-inflammatory activity. Biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence o...

Aldehydes, ketones, carboxylic esters, carboxylic amides, imines and N,N-disubstituted hydrazones react as electrophiles at their sp2-hybridized carbon atoms. These compounds also become nucleophiles, if they contain an H atom in the a-position relative to their C O or C N bonds. This is because they can undergo tautomerization to the corresponding enol as seen in Chapter 12. They are also C,H-...

A novel series of esters 8-10 and hydrazones 4-6 was synthesized from 4-aryl-2-phenacylidene-1,3,4,5-tetrahydropyrido[2,3-b][1,4]diazepine (1-3). Subsequent treatment of hydrazone 4 with p-chlorbenzaldehyde furnished azine 7. Long-standing heating of ester 8 with hydrazine hydrate afforded 3-[1-(p-chlorophenylene)-2-(5-phenyl-1H-pyrazol-3-yl)-ethyl]-1,3-dihydroimidazo[4,5-b]pyridin-2-one (11). ...

a-Acyl-a-cyanocarbonyl-phenylhydrazones are effective uncouplers of oxidative phosphorylation. The p/50-values of a series of 60 hydrazones with substituent variations in six positions of the molecule were determined in rat liver mitochondria. They ranged from 4.96 to 7.06. The biological data together with physico-chemical compound and substituent parameters were analysed by multiple regressio...

The purpose of this work is the synthesis new isonicotinic acid hydrazones, study their structure, reactivity and biological screening some synthesized compounds. reactions leading to N-arylidene(alkylidene) hydrazones via condensation hydrazide with various derivatives aromatic aldehydes were studied. structure functionally substituted was established by FTIR, 1H 13C NMR, two-dimensional COSY ...