Lipogenesis from propionate-l-Cl4 was first reported by Feller and Feist (2) in slices of liver and adipose tissue. Favarger and Gerlach (3, 4) and Masoro and Porter (5) recently studied the incorporation of propionate-1-V into fatty acids of rat and mouse adipose tissue in viva and in vitro. The incorporation of propionate, compared with that of acetate, was quite low. Favarger and Gerlach (4)...

Modulatory effects of l-carnitine, acetate, propionate, and 5-tetradecyloxy-2-furoic acid (TOFA; an inhibitor acetyl-CoA carboxylase) on oxidation esterification [1-14C]-palmitate were studied in hepatocytes isolated from phlorizin-treated control wethers. Our hypotheses that (1) palmitate would be greater sheep injected with phlorizin; (2) l-carnitine increase more (3) acetate propionate decre...

Propionate disappearance from the loops of the hindgut in the rabbit was evaluated by measuring variations in the concentration of propionate in caecocolonic loops and differences in the arterial and venous plasma. In vivo metabolism in gut and liver tissues was studied after introduction of (1-14C) propionate into the caecocolonic loops. The rate of disappearance from the loops was always quan...

Incorporation of amino acids into proteins in HeLa cells, virus-transformed 3T3 mouse fibroblasts, and mouse plasmacytoma cells is inhibited after the addition of L-l-tosylamido-Z-phenylethyl chloromethyl ketone, an alkylating agent and chymotrypsin-specific protease inhibitor. Addition of this drug to tissue culture cells at concentrations of 20 to 30 c(g per ml results in an irreversible inhi...

The aim of this study was to evaluate the effects of alginate entrapment on fermentation metabolites of Kluyveromyces marxianus grown in agrowastes that served as the liquid culture media. K. marxianus cells entrapped in Na-alginate were prepared using the traditional liquid-droplet-forming method. Whey and pomaces from processed tomatoes, peppers, and grapes were used as the culture media. The...

1. The rate of gluconeogenesis from propionate in rat kidney-cortex slices was stimulated up to 3.5-fold by dl-carnitine and by bicarbonate, and was inhibited by inorganic phosphate or high concentrations of propionate (above 3mm). 2. The stimulatory effect of carnitine was dependent on the bicarbonate concentration and could be replaced at low propionate concentration by addition of 25mm-bicar...

Feeding and postruminal infusion of propionate is known to increase N retention in ruminants. Our aim was to determine the role of rumen propionate on urea N recycling and gluconeogenesis in growing sheep. In Exp. 1, wether sheep ( = 6; 32.5 ± 3.57 kg BW) fitted with a rumen cannula were fed to 1.8 × ME requirement a concentrate-type ration (172 g CP/kg DM and 10.4 MJ ME/kg DM) and continuously...

Glucose entry rates, propionate production rates and the conversion of propionate into glucose were measured in sheep given diets varying in protein and energy content. Glucose entry rate increased linearly (P<O.Ol ) with the estimated intake of digestible energy and with crude protein intake as did concentrations in the rumen of propionate and total VFA. There was, however, little variation in...

TADA, K. and ARAKAWA, Ts. Hyperglycinemia and propionate carboxylation. Tohoku J. exp. Med., 1970, 102 (3), 313-314 The oxidation of propionate and methylmalonate was investigated in leukocytes from a patient with hyperglycin emia. It was found that the patient's leukocytes could oxidize both propionate and methylmalonate normally. These findings suggest that hyperglycinemia con sists of primar...

Inhaled corticosteroids form the mainstay of the treatment and management of asthma and the results of a meta-analysis comparing two of the most frequently prescribed inhaled corticosteroids, fluticasone propionate and budesonide, administered in a clinically equivalent 1:2 dose ratio to 1980 patients with asthma, demonstrated that fluticasone propionate had an improved efficacy:safety ratio. H...