Original Article Context: Cilnidipine, an N-type and L-type calcium channel blocker has been reported to have antihypertensive, renoprotective and neuroprotective effect. In this present study we evaluated anti-epileptic effect of cilnidipine in experimentally induced convulsions in Mice. Aims: To evaluate the anti epileptic effect of cilnidipine. Materials and Methods: Cilnidipine, phenytoin s...

This calculator uses the revised versions of the Winter-Tozer correction this method has now been shown to poorly correlated with free phenytoin levels., . Phenytoin. μg/mL. Albumin. g/dL. Creatinine clearance < 20 ml/min. No. Yes. About the Creator. Dr. Thomas N. Tozer. Related Calcs. Ca Correction for Albumin . Jul 25, 2017. The program accomplishes this by utilizing the Sheiner-Tozer equatio...

STUDY OBJECTIVE To determine the value of fosphenytoin compared with phenytoin for treating patients admitted to an emergency department following a seizure. DESIGN Cost-minimization analysis performed from a hospital perspective. SETTING Hospital emergency department. PATIENTS Two hundred fifty-six patients participating in a comparative clinical trial. INTERVENTION Estimation of adver...

The major phenytoin metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin glucuronide (HPPG), was primarily responsible for the positive bias noted when uremic specimens were assayed with the Abbott TDx Free Phenytoin fluorescence polarization immunoassay. The amount of bias depended on both HPPG and phenytoin concentration, increasing with increases in either concentration. The new Abbott TDx II a...

In order to evaluate the effects of phenytoin on the reproductive system of rats in detail, 60 male rats were divided equally into 6 groups: 1-5 received 10 mg/kg/day phenytoin IP for 1,2,3,4 and 5 weeks, respectively. However, group 5 did not receive any phenytoin for the last 5th week. The control group (group 6) did not receive any treatment. The results revealed that phenytoin does not ...

introduction: interaction between drugs represents a major clinical concern for health care professionals and their patients. patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin  concurrently. the aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. according to t...

We describe a patient in whom phenytoin toxicity developed soon after treatment with parenteral miconazole. A 51 year old man was admitted for treatment of recurrent severe haemoptysis associated with pulmonary aspergillosis. He was in chronic respiratory failure. He was a non-smoker. Biochemical 'indices of liver function were normal. There was a past history of asthma and also of epilepsy for...

The cross-reactivity of fosphenytoin, a phosphate ester prodrug of phenytoin, was investigated in the Abbott phenytoin TDx/TDxFLx fluorescence polarization immunoassay (TDx) and the Behring Diagnostics phenytoin Emit 2000 enzyme-multiplied immunoassay (Emit). The first part of our study investigating cross-reactivity utilized in vitro correlation of the two immunoassays with a validated and spe...

A chromatographic method was developed for measuring free drug fractions based on the use of an ultrafast immunoextraction/displacement assay (UFIDA) with near-infrared (NIR) fluorescent labels. This approach was evaluated by using it to determine the free fraction of phenytoin in serum or samples containing the binding protein human serum albumin (HSA). Items considered in the design of this m...

There were significantly more diffuse and focal electroencephalographic abnormalities in 127 mentally retarded epileptic patients treated with phenytoin than in 68 epileptics without phenytoin. Phenytoin intoxication made the difference still more pronounced. Monitoring drug levels and electroencephalograms appears to be the method of choice for ensuring safe and effective medication in intract...