The physiological heart rate of rodents is around 4-6 Hz, although a stimulus frequency 1 Hz generally used in isolated cardiomyocytes to study changes the contraction-relaxation cycle cardiac muscle physiology and pathophysiology. Our investigated contraction parameters at 1, 2 4 stimulation, roles ATP protein kinase A (PKA) force-frequency relationship cardiomyocytes. cell intracellular Ca2+ ...

In the neural engineering field, physiological dysfunctions are approached by identifying the target nerves and providing artificial stimulation to restore the function. Neural stimulation and recording technologies play a central role in this approach, and various engineering devices and stimulation techniques have become available to the medical community. For bladder control problems, electr...

The current study evaluated the effects of a methanol extract from Chaetomorpha aerea (a green alga) on non-specific immune responses and resistance against Edwardsiella tarda infection in Labeo rohita. Different doses (5, 50 500 mg/kg body weight) were injected into fish intraperitoneally while control group was with 0.2 mL sterile physiological salt solution. Variations several immunostimulat...

The importance of mechanotransduction for physiological systems is becoming increasingly recognized. The effect of mechanical stimulation is well studied in organs and tissues, for instance by using flexible tissue culture substrates that can be stretched by external means. However, on the cellular and subcellular level, dedicated technology to apply appropriate mechanical stimuli is limited. H...

the aim of most pharmacotherapy for Parkinson’s disease (PD). The theoretical background to CDS is that the physiological striatal dopaminergic stimulation is constant and that oral therapy with levodopa in PD can replace dopaminergic stimulation only in an intermittent, non-physiological manner.1,2 This pulsatile stimulation of the dopamine receptors is thought to contribute to the development...

β-adrenergic stimulation is a key regulator of cardiac function. The localization of major cardiac adrenergic receptors (β1 and β2) has been investigated using biochemical and biophysical approaches and has led to contradictory results. This study investigates the functional subcellular localization of β1- and β2-adrenergic receptors in rat ventricular myocytes using a physiological approach. V...

a b s t r a c tthe applications of neurophysiological therapy techniques range far and few in the realm of modern day medicine. however, the concept of electromagnetic stimulation, the basis for many noninvasive brain stimulation (nibs) techniques today, has been of interest to the scientific community since the late nineteenth century. recently, transcranial direct current stimulation (tdcs) a...

Electrical nerve fiber stimulation is a technique widely used in prosthetics and rehabilitation, its study from computational point of view can be useful instrument to support experimental tests. In the last years, there was an increasing interest modeling neural cells numerical simulations on fibers because usefulness forecasting effect electrical current stimuli delivered tissues through impl...

Electrical stimulation of the nervous system is attracting increasing attention because of the possibilities it offers for physiological investigations, clinical diagnosis, muscle function assessment, noninvasive muscle characterization, and functional control of paralyzed extremities. Parameters of the myoelectric signal evoked by surface stimulation of a muscle motor point or by stimulation o...