XIAOMEI GU: Physiopathology of Osteoclast in Bone (Under the direction of Dr. Eric T. Everett) Bone is constantly remodeled by osteoclastic bone resorption and osteoblastic bone formation. Abnormal remodeling can result in bone mass change; bone loss is implicated in a number of bone diseases, representing an increase in bone resorption relative to formation. Therefore, an understanding of oste...

Asthma is a chronic inflammatory airway disease characterized by allergen-induced airway hyperresponsiveness, airway inflammation, and remodeling. Nitric oxide (NO) derived from constitutive and inducible enzymes affects many aspects of asthma physiopathology. Animal in vivo studies have indicated that inhibition of iNOS may play a central role in the modulation of these features, particularly ...

introduction: an evaluation of the curriculum elements can be recognized as a necessity in curriculum dynamic and improvement. this study aimed at evaluating five main elements of a physiopathology curriculum in internal medicine (objectives, content, methods, evaluation, and management). method: the present study is of a descriptive-analytical type, and the study population consisted of a tota...

Lipoprotein(a) (also called Lp(a)) is a lipoprotein subclass. Different studies have identified Lp(a) as a putative risk factor for atherosclerotic diseases such as coronary artery disease and stroke. The physiological role of Lp(a) in humans is still unclear, but it seems that individuals with low concentrations of plasma Lp(a) manifest no deficiency syndrome or disease. Because of the high ho...

The adult onset Still’s disease is a rare affection characterised by occurrence of fever, arthralgia or arthritis and evanescent cutaneous eruption. Multiple other systemic lesions make the diagnosis more difficult. Several diagnostic criteria were formulated to confirm this disease. The physiopathology of the adult onset Still’s disease is not well elucidated. However, several studies based on...