The effects of inhaled stable xenon gas on cerebral blood flow were studied with 23 transcranial Doppler examinations performed in 13 normal volunteers while breathing, 25, 30, or 35% xenon for 5 min. Doppler velocities from the middle cerebral artery rose significantly during inhalation in 85% of subjects and 78% of studies and decreased significantly in 15% of subjects and 17% of studies. The...

Partial exchange transfusion with a cell-free hemoglobin (Hb) polymer during transient middle cerebral artery occlusion (MCAO) reduces infarct volume but fails to increase blood flow, as might be expected with the induced decrease in hematocrit. In ischemic brain, endothelin antagonists are known to produce vasodilation. In nonischemic brain, pial arterioles constrict after Hb exchange transfus...

Objective and Impact Statement . This study examined the efficacy safety of pulsed, low-intensity focused ultrasound (LIFU) determined its ability to provide neuroprotection in a murine permanent middle cerebral artery occlusion (pMCAO) model. Introduction Focused (FUS) has emerged as new therapeutic strategy for treatment ischemic stroke; however, nonthrombolytic properties remain ill-defined....

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...

Letter by Shang Regarding Article, “Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation” To the Editor: The recent publication by Hamner and Tan, titled Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation, was of great interest to our group. They analyzed the relationship between specific physi...

The mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. To examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit.Cerebral blood flow was measured by laser Doppler flow-meter in 18 NZW rabbits anesthetized with sodium pentobarbital.  Tetrodetoxin ...

A 64-year-old man presented with left-sided weakness with an initial NIH Stroke Scale score of 11. Brain CT imaging showed a hyperdense artery sign of right middle cerebral artery (MCA) occlusion (figure 1, A and B). Brain MRI showed the susceptibility vessel sign (SVS) on gradient recalled echo and hyperintense vessels (HV) on fluid-attenuated inversion recovery images (figure 1, C and D). Ang...

We evaluated the effects of cilostazol, a selective inhibitor of cyclic adenosine monophosphate phosphodiesterase, on the pial vessels of adult cats subjected to endothelial damage followed by middle cerebral artery occlusion. Six cats were treated with cilostazol and four with 30% N,N-dimethylformamide in 70% saline (solvent). The brain surface was irradiated with ultraviolet rays through a cr...