Introduction : The present study is aimed at investigation of the mechanism action a new 3-substituted thietane-1,1-dioxide derivative (N-199/1) exhibiting antidepressant properties, in several tests neuropharmacological interaction. Materials and methods To N-199/1, its effect on 5-hydroxytryptophan (5-HTP)-induced head-twitch response (50 mg/kg 300 mg/kg), haloperidol-induced catalepsy (1 are...

P icrotoxin (PTX) is the prototypic antagonist of GABAA receptors (GABARs), the primary mediators of inhibitory neurotransmission (rapid and tonic) in the nervous system. Picrotoxinin (Fig. 1A), the active ingredient in this plant convulsant, structurally does not resemble GABA, a simple, small amino acid, but it is a polycylic compound with no nitrogen atom. The compound somehow prevents ion f...

The effects of GABA and related agents were studied in solitary rod- and cone-driven horizontal cells, acutely isolated from the catfish retina using enzymatic and mechanical treatment. Both types of horizontal cells, which normally receive glutamatergic input from photoreceptors, responded to pressure ejection of the glutamate analog kainate (50 microM) with an inward current of 300-800 pA whe...

introduction: aggressive behavior is a major issue in the field of mental health. pharmacotherapy is often used for the treatment of violent individuals. a neurochemical system most consistently linked with aggression is the gabaergic system. the aim of the present investigation was to examine the effect of muscimol (gabaa agonist) 250 and 500 ng/rat and picrotoxin (gabaa antagonist) 1.5 and 3 ...

the present work was performed to show the possible interaction of gab a, and gabab receptors in catalepsy. the following results were obtained: 1- muscimol (mus), a gabaa agonist, induced catalepsy. this effect was dose-dependent. baclofen (bac), a gabab agonist, had no effect in this respect. 2- catalepsy induced by muscimol was potentiated by pretreatment of animals with bicuculline (bic), a...