Paroxysmal nocturnal hemoglobinuria (PNH) is clinically characterized by intravascular hemolysis, hemoglobinuria, iron deficiency anemia, and venous thrombosis. Pathophysiologically the disease has now been generally accepted as an acquired defect of phosphatidylinositol glycan (PIG)-anchored molecules on the cell surface of bone marrow-derived cells. This defect is functionally characterized b...

During the course of an investigation of the components involved in the electron transport pathway in Pseudomonas $uorescens (1)) the problem arose as to the nature of the carriers mediating the transfer of electrons between the diaphorase and bacterial cytochrome c. Mahler and Elowe (2) have reported the involvement of iron as a component of the DPNH’ cytochrome c reductase from pig heart. Rem...

Background: Species identification in commercially processed food and feed products is one of the important issues. This study was conducted to develop a genetic method for the detection of pig and cattle species in processed food and feed products using newly designed species-specific primers targeting mitochondrial 12S rRNA gene fragments. Methods: Two sets of specific primers were designed ...

The aim of the present study was to determine the correlation between dual-energy computed tomography (DECT) Hounsfield units (HU) and iron concentration, as well as the correlation between HU and magnetic resonance imaging (MRI)-derived R2* values, in phantoms of the heart and liver tissue. Phantoms were constructed containing pig heart or liver tissue and varying concentrations of iron (0.1, ...

CONRAD, MARCEL E., LEWIS R. WEINTRAUB, DAVID A. SEARS, AND WILLIAM H. CROSBY. Absorption of hemoglobin iron. Am. J. Physiol. 2 I I (5) : I I 23-1 I 30. rg66.-Hemoglobin-iron was absorbed by the guinea pig as an iron-containing porphyrin compound. Absorption of both inorganic and hemoglobin-iron occurred primarily in the duodenum but about onethird of the quantity absorbed from the gut can be ab...

Man has known that iron plays an important role in health and disease for considerable time (Loosli, 1978). Bryan (1931) stated that documented therapeutic use of iron date back as far as 1500BC. Iron was recognised as vital nutrient for animal (Boussingault, 1872). Braasch (1981) was the first to describe anaemia in nursing pigs that were being reared in confinement in Germany. However, he did...

Short-term cultures of guinea pig eryththesizing cells only slightly. In the roblasts permitted observation on the presence of potassium cyanide, which micropinocytosis (rhopheocytosis) of ferinhibits iron transport markedly, ferritin ritin. In the presence of enzymes that atincreased two-seven times over controls. tack the cell surface (neuraminidase and The data are compatible with the notryp...