نتایج جستجو برای: piperazine derivative
تعداد نتایج: 65723 فیلتر نتایج به سال:
The gelation properties of a zinc porphyrin bearing peripheral urea groups (1 x Zn) were evaluated in the absence and the presence of several diamines. In aromatic solvents such as benzene, toluene and p-xylene, 1 x Zn only provided the precipitate. In contrast, 1 x Zn with 0.5 and 1.0 equiv. of piperazine formed gels, and the gel with 0.5 equiv. of piperazine showed a unique physical property ...
The temperature-dependence of the influence of the position-2-methyl group on the structure-directing effect of piperazine in the synthesis of open-framework aluminophosphates was investigated. By heating the initial mixture with the composition of Al2O3:1.5 P2O5:R:125 H2O at 160 °C, where R is the structure-directing agent of 2-methylpiperazine or piperazine, layered aluminophosphates APMeP150...
The in vitro and in vivo metabolism of N-[1(R)-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2(S)-[4-[(4-methy l-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide (L-694,458) was studied in male Sprague-Dawley rats and rhesus monkeys. Analysis by LC-MS/MS and NMR revealed that the major metabolite generated in incubations with rat liver microsomes resulted from N-oxidation of the piperazi...
The title compound, C12H18N4O2, crystallizes in the zwitterionic form with protonation at the N atom of the piperazine ring bearing the carboxylate group. The piperazine ring adopts a slightly distorted chair conformation. In the crystal, N-H⋯O hydrogen bonds are observed, forming chains along [010]. The packing is consolidated by C-H⋯O inter-actions, which generate a three-dimensional network.
quinolones are broad-spectrum antibacterial agents.they have many clinical uses which are increasing.quinolones exert antibacterial activity primarily by inhibiting bacterial DNA gyrase.the inhibition of DNA gyrase by the quinolones are greatly influenced by the nature of the C-7 substituent on the quinolones molecule.substitution of bulky functional groupd is also possible in C-7 position.furt...
In the title compound, C14H18N4, the piperazine ring is in a slightly distorted chair conformation. The indole ring system is twisted from the piperazine ring, making a dihedral angle of 7.27 (11)°. In the crystal, N-H⋯N hydrogen bonds link mol-ecules into chains along [10-1].
Tetramisole, a new synthetic anthelmintic, was compared with piperazine in the treatment of ascariasis in African children. Of 100 children receiving tetramisole 94 were cured, and of 100 given piperazine 85 were cured (0.05>P>0.02). Tetramisole was free of side-effects.
Historically, ecstasy tablets contained 3,4-methylenedioxymethamphetamine (MDMA) as the psychoactive component. In recent years, the Drug Enforcement Administration (DEA) and other law enforcement agencies have seized ecstasy tablets that are comprised of psychoactive drugs or drug mixtures other than MDMA. Many jurisdictions have reported the presence of piperazine derivatives including 1-benz...
In the titile compound, C(18)H(20)Cl(2)N(2)O(2), the piperazine ring adopts a chair conformation. The mol-ecule has a non-crystallographic inversion centre in the middle of the piperazine ring at approximate position (3/4, 1/8, 3/8). There are intra-molecular O-H⋯N hydrogen bonds forming S(6) ring motifs. Inter-molecular C-H⋯O hydrogen bonds generate anti-parallel C(5) chain motifs propagating ...
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