Pleural metastases are common in patients with advanced thoracic cancers and are a cause of considerable morbidity and mortality yet is difficult to treat. Near Infrared Photoimmunotherapy (NIR-PIT) is a cancer treatment that combines the specificity of intravenously injected antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to NIR-light. Herein, we ev...

The transcription factor Pit-1/Pou1f1 regulates GH and prolactin (PRL) secretion in the pituitary gland. Pit-1 expression and GH regulation by Pit-1 have also been demonstrated in mammary gland. However, no data are available on the role of Pit-1 on breast PRL. To evaluate this role, several human breast cancer cell lines were transfected with either the Pit-1 expression vector or a Pit-1 small...

Pavlovian-to-instrumental transfer (PIT) is an effect whereby a classically conditioned stimulus (CS) enhances ongoing instrumental responding. PIT has been extensively studied with appetitive conditioning but barely at all with aversive conditioning. Although it's been argued that conditioned suppression is a form of aversive PIT, this effect is fundamentally different from appetitive PIT beca...

theoretical review of ‘mining pit lakes’ indicates that like natural lakes such lakes display a huge diversity. they are typically in a non-equilibrium state with respect to their surroundings. hence, at the decommissioning phase of mining operation a detailed technical study are required on different aspects of such created water bodies considering its morphometry, geology, hydrology, water qu...

As is so often the case with the archaeological record for Derbyshire there is in the early medieval period a marked contrast between the types of evidence which characterise the Peak District and that from the areas to the south and east. The evidence in the Peak District is dominated by the seventh century barrow burials and the later stone crosses and other sculptural remains. Outside the Pe...

PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the...

Ultimate limits of an open pit, which define its size and shape at the end of the mine’s life, is the pit with the highest profit value. A number of algorithms such as floating or moving cone method, floating cone method II and the corrected forms of this method, the Korobov algorithm and the corrected form of this method, dynamic programming and the Lerchs and Grossmann algorithm based on grap...

Transportation costs are a significant part of capital and operating costs of large open pit mines. Cost efficiency and high reliability of in pit crushing and conveying systems compared to conventional truck-shovel system makes it more appealing to be utilized in modern mining activities. In this paper the suitable location of an in pit crusher is investigated as a single hub location problem....

In the autumn of 2008 human and animal bones came to light during the cabling works in the village of Salme, on the island of Saaremaa, Estonia. Some days later a contour of an ancient boat was discovered. The ancient boat, as well as human and animal bones inside it, dates to the second half of the 7 century or the beginning of the 8 century. The osteological analyses of the human bone materia...