نتایج جستجو برای: place aversion
تعداد نتایج: 209660 فیلتر نتایج به سال:
Relapse triggered by drug-paired cues is a major obstacle for successful treatment of drug abuse. Patterns of brain activation induced by drug-paired cues have been identified in human and animal models, but lack of specificity poses a serious problem for craving or relapse interpretations. The goal of this study was to compare brain responses to contextual cues paired with a rewarding versus a...
Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targeted drug development has been largely ineffective. An alternative approach to analgesic development would be to develop low cost, high throu...
introduction: the influence of ascorbic acid on the nicotine-induced conditioned place preference (cpp) and behavioral sensitization was investigated in the present study. methods: in a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. different doses of ascor...
We examined the role of glutamatergic transmission within the basolateral amygdaloid nucleus (BLA) in pain-induced aversion using a conditioned place paradigm and an in vivo microdialysis technique in rats. Microinjection of MK-801 (1 or 10 nmol/side) into the bilateral BLA 5 min before intraplantar injection of formalin dose-dependently attenuated formalin-induced conditioned place aversion (F...
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