purpose: to compare the effect of high dose intravenous corticosteroid therapy with placebo in the treatment of recent traumatic optic neuropathy (ton). methods: in a double masked-placebo controlled clinical trial, 31 eyes of 31 patients were randomly assigned into two groups. only patients with history of ophthalmic or head trauma within the past 7 days were included. unconscious patients, th...

INTRODUCTION Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). During the clinical development programme, increases in mean serum creatinine (SCr) of approximately 0.07 mg/dL and 0.08 mg/dL were observed which plateaued early. This study assessed changes in measured glomerular filtration rate (mGFR) with tofacitinib relative to placebo in patients wit...

Background: Primary dysmenorrhea is the common gynecologic problems, particularly among adolescent girls. The pain severe during first and/or second day of bleeding & usually lasts up to 72 hours. More than 55 80% post-menarche women are thought experience primary dysmenorrhea. Both vitamin E and a placebo may lessen dysmenorrhea-related pelvic pain, although appears do more significantly O...

Abstract Introduction KarXT combines the M 1 /M 4 preferring muscarinic receptor agonist xanomeline and peripherally restricted anticholinergic trospium. In phase 2 EMERGENT-1 study, met primary endpoint of a significant reduction in Positive Negative Syndrome Scale (PANSS) total score through week 5 vs placebo, improved other key secondary efficacy measures, was generally well tolerated. Metho...

Abstract Children with atopic dermatitis (AD) are at risk for lower bone mineral density (BMD) and alkaline phosphatase (ALP) levels than healthy children. Low BMD ALP in children could contribute to a higher lifetime prevalence of fractures, osteopenia osteoporosis. Dupilumab is fully humanized monoclonal anti-interleukin (IL)-4R antibody approved the treatment AD The objective this analysis r...

strenuous aerobic exercise is associated with oxidative stress and tissue damage. therefore, we have investigated the effects of exercise and eicosapentaenoic acid supplementation, with or without vitamin e, on the plasma levels of vitamin c, e and a, il-6, and glutathione peroxidase activity in basketball players. thirty four male basketball players, enrolled in the study. subjects received 2g...

To evaluate efficacy and safety of budesonide oral suspension (BOS) in pediatric patients with eosinophilic esophagitis (EoE). We used pooled data from two 12-week, randomized, double-blind, placebo-controlled trials BOS 2.0 mg b.i.d. (phase 2 [MPI 101-06/NCT01642212] phase 3 [ORBIT1/SHP621-301/NCT02605837]) aged 11–17 years EoE dysphagia. Peak eosinophil counts, the Dysphagia Symptom Questionn...

Aim To evaluate the efficacy, safety, and tolerability of apararenone 10 mg/day in patients with nonalcoholic steatohepatitis (NASH). Methods In this multicenter, randomized, double-blind, placebo-controlled phase II study, received mg or placebo once daily for 72 weeks. The primary efficacy end-point was percent change serum alanine aminotransferase (ALT) from baseline to 24 weeks after random...

Abstract Background Bacterial infection is an important cause of diarrhea in children, potentially leading to malnutrition, growth and development disorders, even death. Antibiotic abuse resistance are widespread problems worldwide, especially China. We therefore designed a study evaluate the clinical efficacy mechanism traditional Chinese medicine alleviating effects antibiotic childhood bacte...

Main results 27 trials were included. 6 trials evaluated topical treatments (follow up of 2 d to 6 wk). Of 2 trials that compared a lidocaine patch with placebo, 1 showed no difference and 1 showed a reduction in pain with lidocaine. 2 trials showed greater pain relief with capsaicin 0.075% cream than with placebo. 2 trials comparing benzydamine cream with placebo showed no difference between g...