An increased tissue content of PC-1, an inhibitor of insulin receptor signaling, may play a role in insulin resistance. Large scale prospective studies to test this hypothesis are difficult to carry out because of the need for tissue biopsies. The aim of this study was to investigate whether PC-1 is measurable in human plasma and whether its concentration is related to insulin sensitivity. A so...

Objective: The recent study aimed to investigate the effects of chronic aerobic activity on the plasma levels of orexin A, leptin, glucose, insulin, and insulin resistance in males with type 2 diabetes. Materials and Methods: Twenty subjects randomly assigned into control and experimental groups, involving 10 people in each group. Exercise protocol consisted of eight session aerobic exercise...

Insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome X, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. Insulin resistance can be induced by fructose-rich diet in rats. We investigated the effect of vanadyl sulfate (0.2 mg...

We characterise the bolus insulin input which minimises maximum plasma glucose concentration predicted by Magdelaine and Bergman minimal models in response to any positive bounded disturbance whilst remaining above a fixed lower concentration. This characterisation is terms of maxima minima limits controllability such systems. Any further attempt will result hypoglycaemia.

this article describes a simple and fast high-performance liquid chromatography method for the determination of methotrexate (mtx) in plasma. samples were collocted from children receiving high-dose mtx at shafa hospital (ahvaz university of medical sciences, ahvaz, iran) at various times after the end of eachinfusion. plasma was deproteinized with trichloroacetic acid and the supernatant was i...

objective: the recent study aimed to investigate the effects of chronic aerobic activity on the plasma levels of orexin a, leptin, glucose, insulin, and insulin resistance in males with type 2 diabetes. materials and methods: twenty subjects randomly assigned into control and experimental groups, involving 10 people in each group. exercise protocol consisted of eight session aerobic exercise. e...

Fasting hyperinsulinemia is a widely used surrogate measure of insulin resistance and predicts type 2 diabetes in various populations. Whether fasting hyperinsulinemia predicts diabetes independent of insulin resistance is unknown. In 319 Pima Indians with normal glucose tolerance, fasting plasma insulin concentration and insulin-stimulated glucose disposal (M) (hyperinsulinemic clamp) were inv...

BACKGROUND Insulin-mediated glucose uptake in insulin target tissues is correlated with interstitial insulin concentration, rather than plasma insulin concentration. Therefore, insulin delivery to the interstitium of target tissues is very important, and the endothelium may also play an important role in the development of insulin resistance. METHODS After treating bovine aortic endothelial c...